DSpace About DSpace Software 日本語

01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2020年度 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3756

Title: Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features.
Other Titles: ミスマッチ修復遺伝子発現欠損を伴う子宮体癌のMRI所見と臨床像
Authors: Minamiguchi, Kiyoyuki
Takahama, Junko
Uchiyama, Tomoko
Taiji, Ryosuke
Saito, Natsuhiko
Okada, Hiroshi
Marugami, Nagaaki
Tanase, Yasuhito
Kawaguchi, Ryuji
Ohbayashi, Chiho
Kobayashi, Hiroshi
Hirai, Toshiko
Kichikawa, Kimihiko
Keywords: Uterus
Endometrial carcinoma
MMR deficiency
Lynch syndrome
Issue Date: Jul-2018
Publisher: Springer
Citation: Japanese journal of radiology Vol.36 No.7 p.429-436 (2018 Jul)
Abstract: Purpose: The purpose of this study was to identify the magnetic resonance imaging (MRI) features of uterine endometrial carcinoma (EC) with DNA mismatch repair (MMR) deficiency. Materials and methods: This was a retrospective study approved by our institutional review board. The study included 118 patients pathologically diagnosed as having EC in our institution from April 2014 to December 2016. Of 118 patients, 8 were excluded because of insufficient data. Immunohistochemical analysis of MMR was performed retrospectively to observe the expressions of MLH1, MSH2, MSH6, and PMS2. A tumor with MMR deficiency was detected in 17 of 110 cases (15%). Clinical background characteristics and MRI findings were reviewed. These findings were compared between MMR deficiency group and the other group as a control group. Statistical significance was determined using the Fisher's exact test and the Mann-Whitney U test, as appropriate. Results: The clinical background characteristics of patients with EC with MMR deficiency were not significantly different from those of other patients. On MRI, the tumor was significantly more often located in the lower uterine site (MMR(-) vs. MMR(+): 29.4 vs. 8.9% [p = 0.0366]). Conclusion: EC with MMR deficiency tends to be located lower in the uterus, though most other findings were not significantly different from those of EC without MMR deficiency.
Description: 博士(医学)・甲第749号・令和2年6月30日
© Japan Radiological Society 2018
© 2018 Springer Nature Switzerland AG. Part of Springer Nature.
This is a post-peer-review, pre-copyedit version of an article published in Japanese journal of radiology. The final authenticated version is available online at: http://doi.org/10.1007/s11604-018-0741-4.
URI: http://hdl.handle.net/10564/3756
ISSN: 18671071
Academic Degrees and number: 24601A749
Degree-granting date: 2020-06-30
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

Files in This Item:

File Description SizeFormat
01甲749本文の要旨.pdf甲749本文の要旨1.31 MBAdobe PDFView/Open
02甲749審査要旨.pdf甲749審査要旨1.14 MBAdobe PDFView/Open
03甲749本文.pdf甲749本文1 MBAdobe PDFView/Open
04甲749Figure.pdf甲749Figure443.14 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback