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このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/3756
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タイトル: | Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features. |
その他のタイトル: | ミスマッチ修復遺伝子発現欠損を伴う子宮体癌のMRI所見と臨床像 |
著者: | Minamiguchi, Kiyoyuki![](/dspace/image/metalink/link_ja.gif) Takahama, Junko![](/dspace/image/metalink/link_ja.gif) Uchiyama, Tomoko![](/dspace/image/metalink/link_ja.gif) Taiji, Ryosuke![](/dspace/image/metalink/link_ja.gif) Saito, Natsuhiko![](/dspace/image/metalink/link_ja.gif) Okada, Hiroshi![](/dspace/image/metalink/link_ja.gif) Marugami, Nagaaki![](/dspace/image/metalink/link_ja.gif) Tanase, Yasuhito Kawaguchi, Ryuji![](/dspace/image/metalink/link_ja.gif) Ohbayashi, Chiho![](/dspace/image/metalink/link_ja.gif) Kobayashi, Hiroshi![](/dspace/image/metalink/link_ja.gif) Hirai, Toshiko![](/dspace/image/metalink/link_ja.gif) Kichikawa, Kimihiko![](/dspace/image/metalink/link_ja.gif) |
キーワード: | Uterus Endometrial carcinoma MMR deficiency MRI Lynch syndrome |
発行日: | 2018年7月 |
出版者: | Springer |
引用: | Japanese journal of radiology Vol.36 No.7 p.429-436 (2018 Jul) |
抄録: | Purpose: The purpose of this study was to identify the magnetic resonance imaging (MRI) features of uterine endometrial carcinoma (EC) with DNA mismatch repair (MMR) deficiency. Materials and methods: This was a retrospective study approved by our institutional review board. The study included 118 patients pathologically diagnosed as having EC in our institution from April 2014 to December 2016. Of 118 patients, 8 were excluded because of insufficient data. Immunohistochemical analysis of MMR was performed retrospectively to observe the expressions of MLH1, MSH2, MSH6, and PMS2. A tumor with MMR deficiency was detected in 17 of 110 cases (15%). Clinical background characteristics and MRI findings were reviewed. These findings were compared between MMR deficiency group and the other group as a control group. Statistical significance was determined using the Fisher's exact test and the Mann-Whitney U test, as appropriate. Results: The clinical background characteristics of patients with EC with MMR deficiency were not significantly different from those of other patients. On MRI, the tumor was significantly more often located in the lower uterine site (MMR(-) vs. MMR(+): 29.4 vs. 8.9% [p = 0.0366]). Conclusion: EC with MMR deficiency tends to be located lower in the uterus, though most other findings were not significantly different from those of EC without MMR deficiency. |
内容記述: | 博士(医学)・甲第749号・令和2年6月30日 © Japan Radiological Society 2018 © 2018 Springer Nature Switzerland AG. Part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Japanese journal of radiology. The final authenticated version is available online at: http://doi.org/10.1007/s11604-018-0741-4. |
URI: | http://hdl.handle.net/10564/3756 |
ISSN: | 18671071 |
DOI: | https://doi.org/10.1007/s11604-018-0741-4 |
学位授与番号: | 24601A749 |
学位授与年月日: | 2020-06-30 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2020年度
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