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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3744

Title: Urinary Nerve Growth Factor Can Predict Therapeutic Efficacy in Children With Overactive Bladder.
Other Titles: 尿中Nerve Growth Factorは、過活動膀胱症状を呈する患児の治療効果の予測因子になる
Authors: Fukui, Shinji
Aoki, Katsuya
Morizawa, Yosuke
Miyake, Makito
Fujimoto, Kiyohide
Issue Date: May-2017
Publisher: Elsevier
Citation: Urology Vol.103 p.214-217 (2017 May)
Abstract: Objective: To assess urinary nerve growth factor (NGF) in children with overactive bladder (OAB) and to investigate the relationship between urinary NGF/creatinine (Cr) levels and OAB. Patients and methods: Thirty-five children (27 boys and 8 girls) with OAB and 11 children (6 boys and 5 girls) without OAB or any other urinary symptoms, who served as controls, were included in this study. Urinary NGF levels were measured using enzyme-linked immunosorbent assay. The total urinary NGF levels were adjusted with the concentration of urinary creatinine (NGF/Cr level). Refractory OAB was defined as little improvement in OAB symptoms despite at least 3 months of urotherapy and anticholinergic agent treatment. Urinary NGF/Cr was compared between the children with OAB and the controls. The relationship between urinary NGF/Cr and treatment outcomes was also evaluated. Results: Urinary NGF/Cr was significantly higher in the children with OAB when compared with those in the control group (0.65 ± 0.82 vs 0.11 ± 0.09, P = .0007). Improvement of OAB symptoms was observed in 26 out of 35 children (74%). The remaining 9 children showed refractory OAB symptoms (the refractory group). Urinary NGF/Cr was significantly higher in the refractory group than in the improved group (1.28 ± 1.34 vs 0.44 ± 0.39, P = .027). Conclusion: Urinary NGF/Cr was significantly higher in the children with OAB than in the controls, and was significantly higher in the refractory group than in the improved group. Urinary NGF/Cr could not only be a potential biomarker for children with OAB, but also a predictor of therapeutic efficacy in children with OAB.
Description: 博士(医学)・乙第1454号・令和2年3月16日
Copyright © 2017 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10564/3744
ISSN: 00904295
Academic Degrees and number: 24601B1454
Degree-granting date: 2020-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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