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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3703

Title: Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis.
Other Titles: ヒト大腸癌肝転移におけるHVEM発現の重要性について
Authors: Sasaki, Yoshiyuki
Hokuto, Daisuke
Inoue, Takashi
Nomi, Takeo
Yoshikawa, Takahiro
Matsuo, Yasuko
Koyama, Fumikazu
Sho, Masayuki
Issue Date: Nov-2019
Publisher: Springer Nature
Citation: Annals of surgical oncology Vol.26 No.12 p.3982-3989 (2019 Nov)
Abstract: Background: Herpesvirus entry mediator (HVEM) has been suggested to play various roles in cancer biology. The authors report that HVEM expression in tumor cells is associated with a reduction in the number of tumor-infiltrating lymphocytes and a poor prognosis after surgical resection in various human gastrointestinal cancers. This study aimed to clarify the clinical significance of HVEM expression in human colorectal liver metastasis (CRLM). Methods: This study examined the cases of 104 patients with CRLM who underwent curative liver resection at Nara Medical University between 2000 and 2014. The median follow-up period was 50.2 months. Immunohistochemical staining was performed using antibodies against HVEM, CD4, CD8, and CD45RO. Results: High HVEM expression was observed in 49 patients (47.1%) with CRLM. Expression of HVEM was not associated with age, gender, administration of preoperative chemotherapy, tumor size, number of tumors, or histologic differentiation. The high-HVEM group exhibited significantly worse overall survival (OS) than the low-HVEM group (P = 0.002). Multivariate analysis showed that high HVEM expression in CRLM, age of 70 years or older, and having five or more tumors are independent poor prognostic factors for OS (hazard ratio [HR], 3.35; 95% confidence interval [CI], 1.41-7.93; P = 0.006). The number of tumor-infiltrating CD8+ and CD45RO+ T cells was significantly lower in the high-HVEM group than in the low-HVEM group. High HVEM expression in primary colorectal cancer was significantly associated with synchronous CRLM, but not with metachronous CRLM. Conclusions: Tumor HVEM expression might play a critical role in CRLM.
Description: 博士(医学)・乙第1447号・令和元年12月5日
© Society of Surgical Oncology 2019
This is a post-peer-review, pre-copyedit version of an article published in Annals of surgical oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-019-07625-z
URI: http://hdl.handle.net/10564/3703
ISSN: 10689265
DOI: http://dx.doi.org/10.1245/s10434-019-07625-z
Academic Degrees and number: 24601B1447
Degree-granting date: 2020-12-05
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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