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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3702

Title: Minodronic Acid in Combination with γδT Cells Induces Apoptosis of Non-small Cell Lung Carcinoma Cell Lines.
Other Titles: ガンマデルタT細胞を介したミノドロン酸の非小細胞肺癌細胞株に対するアポトーシス誘導効果の検討
Authors: Yasukawa, Motoaki
Nakazawa, Tsutomu
Kawaguchi, Takeshi
Kawai, Norikazu
Tsujimura, Takahiro
Tojo, Takashi
Taniguchi, Shigeki
Keywords: Non-small cell lung carcinoma cells
γδ T-cells
bisphosphonate
apoptosis
Issue Date: Nov-2016
Publisher: International Institute of Anticancer Research
Citation: Anticancer research Vol.36 No.11 p.5883-5886 (2016 Nov)
Abstract: Background/aim: Non-small cell lung carcinoma (NSCLC) is one of the leading causes of cancer-related death worldwide. Recent studies showed that nitrogen-containing bisphosphonates (N-BPs) directly and indirectly prevent proliferation, induce apoptosis, and inhibit metastasis of various types of cancer cell. In order to investigate the effect of combining minodronic acid (MDA) with γδ T-cells, NSCLC cells were treated with five concentrations of MDA. Materials and methods: NSCLC cells were cultured with different concentrations of MDA alone or in combination with γδ T-cells for 24 h. Results: MDA with γδ T-cells had differential apoptotic effects on the NSCLC cell lines. The cells showed significant apoptotic effects in the presence of MDA in a dose-dependent manner. Conclusion: This study is the first to report an indirect effect of MDA against NSCLC. We report the induction of apoptosis by MDA in combination with γδ T-cells.
Description: 博士(医学)・乙第1446号・令和元年12月5日
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
発行元の規定により、本文の登録不可。本文は以下のURLを参照 "http://dx.doi.org/10.21873/anticanres.11174"(※全文閲覧は学内限定)
URI: http://hdl.handle.net/10564/3702
ISSN: 02507005
Academic Degrees and number: 24601B1446
Degree-granting date: 2020-12-05
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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