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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3698

Title: Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy.
Other Titles: 近赤外線スベクトロスコピィを用いた小児期自閉スペクトラム症の前頭前野における血液動態反応の低下
Authors: Uratani, Mitsuhiro
Ota, Toyosaku
Iida, Junzo
Okazaki, Kosuke
Yamamuro, Kazuhiko
Nakanishi, Yoko
Kishimoto, Naoko
Kishimoto, Toshifumi
Keywords: Pediatric autism spectrum disorder
Near-infrared spectroscopy
Prefrontal hemodynamic response
Executive function
Issue Date: 28-Jun-2019
Publisher: BioMed Central
Citation: Child and adolescent psychiatry and mental health Vol.13 Article No.29 (2019 Jun)
Abstract: Background: Functional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin. Methods: Twelve drug-naïve male participants, aged 7-15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy. Results: Oxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021-0.0063). Conclusion: The results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.
Description: 博士(医学)・乙第1442号・令和元年12月5日
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
URI: http://hdl.handle.net/10564/3698
ISSN: 17532000
Academic Degrees and number: 24601B1442
Degree-granting date: 2019-12-05
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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