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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.48 No.3 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/368
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| Title: | PHARMACOLOGY WITH A CUP OF COFFEE : DOUBLE-BLIND ANALYSIS FOR ARITHMETIC SKILL AND HEMODYNAMIC EFFECTS |
| Authors: | Satoh, Hiroyasu
Tanaka, Takeshi
Nakashima, Toshikatsu |
| Keywords: | caffeine(coffee)
arithmetic skill
hemodynamic actlons
tolerance |
| Issue Date: | 30-Jun-1997 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.48 No.3 p.141-150 |
| Abstract: | Effects of caffeine on aritlmetic skill test and hemodynamic effects were
investigated after drinking caffeine-free or caffeine-containing (180mg) coffee. The
development of tolerance in habitual coffee-drinkers was also examined. A double-blind
study of 417 healthy medical university students (22.4±2.1 years old) was carried out. Ten
rounds of the arithmetic tests were performed; the first four rounds before, and the
subsequent six rounds after a coffee-break. Each round was composed of three 1-min
arithmetic tests and two 1-min rests between the tests. The arittmetic skill per round was
averaged. Simultaneously, heart rate and blood pressure were also measured once a round.
The mean value of arithmetic skill at the 4th round before coffee-break was 86.7±3.9/
min (n=417). The heart rate and mean blood pressure were 73.7±3.3 beats/min and 85.7
±3.8 mmHg. As compared with caffeine-free group (n=205), caffeine-containing groups
had a significant enhancement of arithmetic skill at 45 to 60 min later. The mean blood
pressure increased at 15 to 90 min, but the heart rate was unaffected. Simultaneously, the
serum concentration of caffeine increased from 0.9±0.3 to 4.3±1.6 ptg/ml (n=12, P〈
0.01) at 45-60min after coffee (180mg caffeine)-drinking. Habitual coffee-drinkers
reduced the stimulations of arithmetic skill and mean blood pressure, as compared with non-
habitual coffee-drinkers. These results indicate that a cup of coffee (containing 180 mg
caffeine) enhances the arithmetic skill and modulates the hemodynamic actions, presum-
ably resulting from stimulation of the central and sympathomimetic nervous systems. A
tolerance to caffeine's actions also develops in habitual coffee-drinkers. |
| URI: | http://hdl.handle.net/10564/368 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.48 No.3
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Files in This Item:
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| 141-150p.Pharmacology with a cup of coffee.pdf | | 1171Kb | Adobe PDF | View/Open |
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