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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3672

Title: Squamous cell carcinoma antigen as a novel candidate marker for amniotic fluid embolism.
Other Titles: Squamous cell carcinoma antigenは羊水塞栓症診断の新しいマーカーとなり得る
Authors: Koike, Natsuki
Oi, Hidekazu
Naruse, Katsuhiko
Kanayama, Naohiro
Kobayashi, Hiroshi
Keywords: amniotic fluid embolism
amniotic fluid-specific protein
squamous cell carcinoma antigen
Issue Date: Dec-2017
Publisher: Wiley
Citation: The journal of obstetrics and gynaecology research Vol.43 No.12 p.1815-1820 (2017 Dec)
Abstract: AIM: We aimed to evaluate the clinical usefulness of serum squamous cell carcinoma (SCC) antigen for the diagnosis of amniotic fluid embolism (AFE). METHODS: Sera and information of 20 patients with AFE (autopsy-proven AFE, four cases; clinical AFE, 16 cases) were obtained from the Japan Amniotic Fluid Embolism Registration Center at Hamamatsu University School of Medicine. As controls, we included 74 gestational-age-matched healthy women who gave birth to healthy newborns during the period from December 2012 to January 2014. Receiver-operator curves (ROC) were used to evaluate the diagnostic performance of SCC levels for prediction of AFE. RESULTS: Serum SCC antigen levels in women with autopsy-proven AFE (112.0 ± 169.4 ng/mL, P = 0.001) and clinical AFE (9.5 ± 10.3 ng/mL, P = 0.004) were significantly higher than those in healthy controls with normal delivery (4.4 ± 2.2 ng/mL). On ROC analysis, the optimal cut-off value for SCC antigen levels was 7.15 ng/mL, for which the sensitivity and specificity for AFE prediction was 60.0% and 89.2%, respectively (area under the ROC, 0.785; 95% confidence interval, 0.663-0.908; P < 0.001). CONCLUSION: Serum SCC antigen may be a promising predictor of the entry of amniotic fluid into the maternal circulation, potentially serving as a candidate marker for noninvasive diagnosis of AFE.
Description: 博士(医学)・乙第1436号・令和元年9月27日
© 2017 Japan Society of Obstetrics and Gynecology
This is the peer reviewed version of the following article: [https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/jog.13453], which has been published in final form at [https://doi.org/10.1111/jog.13453]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
URI: http://hdl.handle.net/10564/3672
ISSN: 13418076
Academic Degrees and number: 24601B1436
Degree-granting date: 2019-09-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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