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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3666

Title: Relationship Between EGFR Expression in Oral Cancer Cell Lines and Cetuximab Antibody-dependent Cell-mediated Cytotoxicity.
Other Titles: 口腔癌細胞株におけるcetuximabを介した抗体依存性細胞障害(ADCC)活性と細胞表面EGFR発現との関連
Authors: Nakamura, Hiroshi
Tamaki, Shigehiro
Yagyuu, Takahiro
Yamakawa, Nobuhiro
Hatake, Katsuhiko
Kirita, Tadaaki
Keywords: Antibody-dependent cell-mediated cytotoxicity
cetuximab
EGFR natural killer cells
oral cancer
Issue Date: Mar-2019
Publisher: International Institute of Anticancer Research
Citation: Anticancer research Vol.39 No.3 p.1275-1282 (2019 Mar)
Abstract: BACKGROUND/AIM: Cetuximab treatment targets the epidermal growth factor receptor (EGFR) overexpressed in oral cancer. This study aimed to investigate the anti-tumour activity of cetuximab against oral cancer cell lines with respect to antibody-dependent cell-mediated cytotoxicity (ADCC), and determine the correlation between ADCC and EGFR expression. MATERIALS AND METHODS: EGFR expression in oral cancer cells was measured by quantitative flow cytometric analysis and immunohistochemistry. ADCC activity was measured by 4-h calcein release assays. RESULTS: Cetuximab-mediated ADCC against oral cancer cells was detectable at a concentration of 0.1 μg/ml. A high correlation was observed between the number of EGFR molecules on the surface of oral cancer cells and ADCC (correlation coefficient: 0.847; p=0.032). CONCLUSION: ADCC is an important mechanism underlying the therapeutic effect of cetuximab, and EGFR expression in tumour cells might serve as a predictive marker to evaluate the effect of cetuximab treatment.
Description: 博士(医学)・甲第721号・令和元年9月27日
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
発行元の規定により、本文の登録不可。本文は以下のURLを参照 "http://dx.doi.org/10.21873/anticanres.13238"(※全文閲覧は学内限定)
URI: http://hdl.handle.net/10564/3666
ISSN: 02507005
Academic Degrees and number: 24601A721
Degree-granting date: 2020-09-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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