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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3582

Title: Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer.
Other Titles: 肝癌に対する経動脈的治療におけるマイクロカテーテル挿入可能ポー トの開発
Authors: Fukuoka, Yasushi
Tanaka, Toshihiro
Nishiofuku, Hideyuki
Sato, Takeshi
Masada, Tetsuya
Tatsumoto, Shota
Marugami, Nagaaki
Sakaguchi, Hiroshi
Kichikawa, Kimihiko
Keywords: Transarterial chemoembolization
Hepatic arterial infusion chemotherapy
Implantable port
Issue Date: Feb-2019
Publisher: Springer Nature
Citation: Cardiovascular and interventional radiology Vol.42 No.2 p.298-303 (2019 Feb)
Abstract: PURPOSE: To develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer. MATERIALS AND METHODS: The design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port. In the in vitro studies, the advance of a microcatheter out of the funnel part was evaluated via seven different septum puncture sites. A 5-Fr indwelling catheter connected to the port was placed in a vascular model, and a microcatheter catheterization was evaluated. In an in vivo study, the port-catheter system was implanted in the hepatic artery in a pig. A microcatheter was percutaneously inserted through the port into the hepatic arterial branches, and embolization was performed. RESULTS: In the in vitro studies, the microcatheter was smoothly advanced out of the port and catheterizations into the hepatic arteries were successful via all septum puncture sites. In the in vivo study, repeated selective embolization through the port was successfully conducted on 7, 14 and 21 days after the implantation. CONCLUSION: The developed implantable port can be used for repeated catheter insertion into the hepatic artery. The combination of repeated TACE and HAIC could be possible using this device.
Description: 博士(医学)・甲第710号・令和元年6月26日
© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018
This is a post-peer-review, pre-copyedit version of an article published in Cardiovascular and interventional radiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00270-018-2111-0.
URI: http://hdl.handle.net/10564/3582
ISSN: 01741551
Academic Degrees and number: 24601A710
Degree-granting date: 2019-06-26
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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