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Vol.48 No.2 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/357

Title: MYASTHENIA GRAVIS ASSOCIATED WITH NEUROPSYCHOSIS : SERUM AUTOANTIBODIES RECOGNIZE NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
Authors: Ueno, Satoshi
Keywords: myasthenia gravis
acetylcholine receptor
neuropsychosis
autoantibody
Issue Date: 30-Apr-1997
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.48 No.2 p.71-76
Abstract: The α₄ subunits of neuronal nicotinic acetylcholine receptor (nAChR) are widely expressed throughoUt the brain, and the α₁ subunits of muscle nAChR are localized at the muscle endplates. Most patients with myasthenia gravis (MG) are seropositive for anti-muscle nAChR antibody, and the peptide comprising residues 125-147 of the human α₁ subunit is myasthenogenic. We synthesized a peptide of the α₄ subunit counterpart of the α₁ 125-147 to investigate cross-reactivity of neuronal nAChR with autoantibodies in MG patients. The synthetic peptide α₄ 160-182 was injected into rabbits, and produced anti- bodies caused a loss of net muscle nAChR. Three myasthenic patients with neuropsy- chiatric symptoms had autoantibodies of which bindings to muscle nAChR were inhibited with anti-α₄ 160-182 antibodies. The serum autoantibodies from these patients recognized the α₄ 160-182.
URI: http://hdl.handle.net/10564/357
ISSN: 04695550
13450069
Appears in Collections:Vol.48 No.2

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