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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.48 No.2 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/357
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| Title: | MYASTHENIA GRAVIS ASSOCIATED WITH NEUROPSYCHOSIS : SERUM AUTOANTIBODIES RECOGNIZE NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS |
| Authors: | Ueno, Satoshi |
| Keywords: | myasthenia gravis
acetylcholine receptor
neuropsychosis
autoantibody |
| Issue Date: | 30-Apr-1997 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.48 No.2 p.71-76 |
| Abstract: | The α4 subunits of neuronal nicotinic acetylcholine receptor (nAChR) are
widely expressed throughoUt the brain, and the α1 subunits of muscle nAChR are localized
at the muscle endplates. Most patients with myasthenia gravis (MG) are seropositive for
anti-muscle nAChR antibody, and the peptide comprising residues 125-147 of the human α1
subunit is myasthenogenic. We synthesized a peptide of the α4 subunit counterpart of the α1
125-147 to investigate cross-reactivity of neuronal nAChR with autoantibodies in MG
patients. The synthetic peptide α4 160-182 was injected into rabbits, and produced anti-
bodies caused a loss of net muscle nAChR. Three myasthenic patients with neuropsy-
chiatric symptoms had autoantibodies of which bindings to muscle nAChR were inhibited
with anti-α4 160-182 antibodies. The serum autoantibodies from these patients recognized
the α4 160-182. |
| URI: | http://hdl.handle.net/10564/357 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.48 No.2
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Files in This Item:
| File |
Description |
Size | Format |
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| 71-76p.Myasthenia gravis associted with neuropsychosis.pdf | | 684Kb | Adobe PDF | View/Open |
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