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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3558

Title: Plaque modification of severely calcified coronary lesions by scoring balloon angioplasty using Lacrosse non-slip element: insights from an optical coherence tomography evaluation.
Other Titles: 冠動脈高度石灰化病変に対するスコアリングバルーンラクロスNon-Slip Elementを用いた冠動脈形成術-光干渉断層法による有用性の評価
Authors: Sugawara, Yu
Ueda, Tomoya
Soeda, Tsunenari
Watanabe, Makoto
Okura, Hiroyuki
Saito, Yoshihiko
Keywords: Percutaneous coronary intervention
Scoring balloon angioplasty
Coronary calcified lesion
Optical coherence tomography
Issue Date: Jul-2019
Publisher: Springer Nature Publishing AG
Citation: Cardiovascular intervention and therapeutics Vol.34 No.3 p.242-248 (2019 Jul)
Abstract: Percutaneous coronary intervention (PCI) for heavily calcified lesions is challenging because these lesions are resistant to balloon dilatation and stenting. Lacrosse non-slip element (NSE) may have the potential to dilate heavily calcified lesions. We aimed to investigate predictors of successful lesion modification using Lacrosse NSE angioplasty via optical coherence tomography (OCT)-guided PCI. We investigated 32 patients with severe target lesion calcification treated with OCT-guided PCI. Successful lesion modification was defined as the complete fracture of calcification after Lacrosse NSE angioplasty. Before PCI, 172 segments with calcification were identified. After pre-dilatation using Lacrosse NSE, successful lesion modification was achieved in 117 segments (68.0%). Calcification was significantly thinner in successfully disrupted segments than in non-disrupted segments (p < 0.001). Calcification angle tended to be larger in disrupted than in non-disrupted segments (p = 0.08). Convex types were less frequently observed in disrupted than in non-disrupted segments (p < 0.001). At minimal lumen area sites, 26 segments (81.3%) were successfully modified. Similar to the overall results, the disrupted group had significantly thinner calcification than the non-disrupted group (p < 0.001). The angle of the calcified plaque was similar between the 2 groups (p = 0.39). Convex-type calcifications were less frequently observed in the disrupted group than in the non-disrupted group (p = 0.05). Receiver-operating characteristic curve analysis showed that calcification thickness < 565 μm was the best predictor of completely disrupted calcification. The thickness and shape of calcifications were predictors of successful lesion modification after Lacrosse NSE angioplasty.
Description: 博士(医学)・乙第1426号・平成31年3月15日
© Japanese Association of Cardiovascular Intervention and Therapeutics 2018
This is a post-peer-review, pre-copyedit version of an article published in Cardiovascular intervention and therapeutics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12928-018-0553-6.
発行元が定める登録猶予期間終了の後、本文を登録予定(2019.08)
URI: http://hdl.handle.net/10564/3558
ISSN: 18684300
Academic Degrees and number: 24601B1426
Degree-granting date: 2019-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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