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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3554

Title: Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy.
Other Titles: ヒストン修飾酵素Setdb2を介したCaveolin-1はインフルエンザ脳症マウスモデルにおける脳浮腫を制御する
Authors: Imakita, Natsuko
Kitabatake, Masahiro
Ouji-Sageshima, Noriko
Hara, Atsushi
Morita-Takemura, Shoko
Kasahara, Kei
Matsukawa, Akihiro
Wanaka, Akio
Mikasa, Keiichi
Ito, Toshihiro
Issue Date: 22-Jan-2019
Publisher: Springer Nature Publishing AG
Citation: Scientific reports Vol.9 No.1 Article No.284 (2019 Jan)
Abstract: Influenza-associated encephalopathy (IAE) is a serious complication that can follow influenza virus infection. Once a cytokine storm is induced during influenza virus infection, tight junction protein disruption occurs, which consequently leads to blood-brain barrier (BBB) breakdown. However, the details of IAE pathogenesis are not well understood. Here, we established a murine IAE model by administration of lipopolysaccharide following influenza virus infection. Brains from IAE model mice had significantly higher expression of type I interferons and inflammatory cytokines. In addition, the expression of Caveolin-1, one of the key proteins that correlate with protection of the BBB, was significantly lower in brains from the IAE group compared with the control group. We also found that, among 84 different histone modification enzymes, only SET domain bifurcated 2 (Setdb2), one of the histone methyltransferases that methylates the lysine 9 of histone H3, showed significantly higher expression in the IAE group compared with the control group. Furthermore, chromatin immunoprecipitation revealed that methylation of histone H3 lysine 9 was correlated with repression of the Caveolin-1 promoter region. These studies identify Caveolin-1 as a key regulator of BBB permeability in IAE and reveal that it acts through histone modification induced by Setdb2.
Description: 博士(医学)・甲第706号・平成31年3月15日
© The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© 2018 Springer Nature Publishing AG
URI: http://hdl.handle.net/10564/3554
ISSN: 20452322
Academic Degrees and number: 24601A706
Degree-granting date: 2019-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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