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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3546

Title: NGF and BDNF expression in mouse DRG after spared nerve injury.
Other Titles: Spared nerve injury後のマウス後根神経節におけるNGFとBDNFの発現
Authors: Terada, Yuki
Morita-Takemura, Shoko
Isonishi, Ayami
Tanaka, Tatsuhide
Okuda, Hiroshi
Tatsumi, Kouko
Shinjo, Takeaki
Kawaguchi, Masahiko
Wanaka, Akio
Keywords: BDNF
Dorsal root ganglion
Neuropathic pain
Spared nerve injury
Issue Date: 1-Nov-2018
Publisher: Elsevier
Citation: Neuroscience letters Vol.686 p.67-73 (2018 Nov)
Abstract: Neuropathic pain is initiated by a primary lesion in the peripheral nervous system and spoils quality of life. Neurotrophins play important roles in the development and transmission of neuropathic pain. There are conflicting reports that the dorsal root ganglion (DRG) in an injured nerve contribute to neuropathic pain, whereas several studies have highlighted the important contribution of the DRG in a non-injured nerve. Clarifying the role of neurotrophins in neuropathic pain is problematic because we cannot distinguish injured and intact neurons in most peripheral nerve injury models. In the present study, to elicit neuropathic pain, we used the spared nerve injury (SNI) model, in which injured DRG neurons are distinguishable from intact ones, and mechanical allodynia develops in the intact sural nerve skin territory. We examined nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model mice. NGF and BDNF levels increased in the injured L3 DRG, while NGF decreased in the intact L5 DRG. These data offer a new point of view on the role of these neurotrophins in neuropathic pain induced by peripheral nerve injury.
Description: 博士(医学)・甲第698号・平成31年3月15日
© 2018 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/10564/3546
ISSN: 03043940
Academic Degrees and number: 24601A698
Degree-granting date: 2019-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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