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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3507

Title: Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis.
Other Titles: ヒト間葉系幹細胞はエオタキシン3/CCR3経路を介して前立腺癌細胞の浸潤能を増加させる
Authors: Ishida, Yukako
Kido, Akira
Akahane, Manabu
Kishi, Shingo
Tsukamoto, Shinji
Fujii, Hiromasa
Honoki, Kanya
Tanaka, Yasuhito
Keywords: Mesenchymal stem cells
Cancer microenvironment
Eotaxin-3
CCR3
Homing chemokines
Issue Date: Sep-2018
Publisher: Elsevier
Citation: Pathology, research and practice Vol.214 No.9 p.1297-1302 (2018 Sep)
Abstract: This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. Among several homing chemokines, an antibody array revealed that expression of eotaxin-3 (but not eotxin-1 and -2) was highly enhanced in MSCs treated with PC-3-conditioned medium. A gene expression array showed significantly increased expression of CCR3, a receptor of eotaxin-3, in PC-3. In a matrigel invasion assay, interferon-gamma, a specific inhibitor of eotaxin-related homing, significantly reduced the transmigration of PC-3 cells, under co-cultured condition with MSCs, in a dose-dependent manner (P < 0.05). Consistent with these results, anti-CCR3 antibody successfully reduced PC-3 migration under the co-cultured condition. These findings suggest that MSCs to modulation of the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis.
Description: 博士(医学)・乙第1424号・平成30年11月30日
© 2018 Elsevier GmbH. All rights reserved.
URI: http://hdl.handle.net/10564/3507
ISSN: 03440338
Academic Degrees and number: 24601B1424
Degree-granting date: 2018-11-30
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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