DSpace DSpace Softwareについて English
 

GINMU >
01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2018年度 >

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/3503

タイトル: Molecular epidemiology and clinical features of extended-spectrum beta-lactamase- or carbapenemase-producing Escherichia coli bacteremia in Japan.
その他のタイトル: 日本における基質拡張型β -ラクタマーゼまたはカルバペネマーゼ産生大腸菌菌血症の分子疫学と臨床的特徴
著者: Komatsu, Yuko
Kasahara, Kei
Inoue, Takashi
Lee, Sang-Tae
Tamamoto, Tetsuro
Yano, Hisakazu
Kirita, Tadaaki
Mikasa, Keiichi
発行日: 2018年8月29日
出版者: Public Library of Science
引用: PloS one Vol.13 No.8 Article No.e0202276 (2018 Aug)
抄録: OBJECTIVES: To identify risk factors and clinical outcomes in patients with bacteremia due to extended-spectrum beta-lactamase (ESBL) or carbapenemase-producing Escherichia coli, as well as to determine the prevalence and genetic background of such isolates. METHODS: Case control study was performed with patients with E. coli bacteremia between January 2008 and May 2013 (n = 115) at a tertiary university hospital in Japan. Cases had ESBL-producing E. coli (ESBL-EC) whereas controls had non-ESBL-producing E. coli (non-ESBL-EC) isolates. A retrospective chart review was performed to identify risk factors and clinical outcomes. Isolates were characterized by antimicrobial susceptibility testing, polymerase chain reaction analysis for beta-lactamase genes, and multi-locus sequence typing. RESULTS: Of 115 unique cases of E. coli bacteremia, 30 (26.1%) were due to ESBL-EC and three (2.6%) were due to carbapenemase-producing E. coli. All three carbapenemase-producing E. coli isolates were IMP-6 and concurrently produced ESBL (ESBL/IMP-6-EC). ESBL-EC isolates showed multidrug resistance. Of the ESBL-EC isolates, CTX-M-27 was the most prevalent (33.3%), followed by CTX-M-14 (30%). Multi-locus sequence typing revealed that 19 (63.3%) isolates were ST131. The multivariate analysis identified nursing home-associated infections and antibiotic administration in the preceding 30 days as risk factors for ESBL-EC bacteremia. The 14-day mortality non-ESBL-EC, ESBL-EC, and ESBL/IMP-6-EC was 4.7% (4/85), 20% (6/30), and 66.7% (2/3), respectively. CONCLUSIONS: CTX-M-27, CTX-M-14, and ST131 were the most prevalent ESBL-EC isolates from bacteremic patients in a Japanese hospital. Further studies with larger sample sizes are warranted to investigate the clinical significance of ESBL-EC and ESBL/IMP-6-EC.
内容記述: 博士(医学)・甲第692号・平成30年11月30日
Copyright: © 2018 Komatsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/10564/3503
ISSN: 19326203
DOI: https://doi.org/10.1371/journal.pone.0202276
学位授与番号: 24601A692
学位授与年月日: 2018-11-30
学位名: 博士(医学)
学位授与機関: 奈良県立医科大学
出現コレクション:2018年度

このアイテムのファイル:

ファイル 記述 サイズフォーマット
01甲692本文の要旨.pdf甲692本文の要旨1.72 MBAdobe PDF見る/開く
02甲692審査要旨.pdf甲692審査要旨724.16 kBAdobe PDF見る/開く
03甲692本文.pdf甲692本文615.11 kBAdobe PDF見る/開く

このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。

 

Valid XHTML 1.0! Powered by DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - ご意見をお寄せください