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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3434

Title: Relationship between frequency spectrum of heart rate variability and autonomic nervous activities during sleep in newborns.
Other Titles: 新生児の睡眠中の心拍変動周波数スペクトルと自律神経活動の関係
Authors: Takatani, Tsunenori
Takahashi, Yukihiro
Yoshida, Ryota
Imai, Ryuko
Uchiike, Takao
Yamazaki, Masaharu
Shima, Midori
Nishikubo, Toshiya
Ikada, Yoshito
Fujimoto, Shinichi
Keywords: EEG
Autonomic nervous system;
Neonatal sleep;
Heart rate variability
Issue Date: Mar-2018
Publisher: Elsevier
Citation: Brain and development Vol.40 No.3 p.165-171 (2018 Mar)
Abstract: INTRODUCTION: We analyzed the frequency spectrum of two neonatal sleep stages, namely active sleep and quiet sleep, and the relationship between these sleep stages and autonomic nervous activity in 74 newborns and 16 adults as a comparison. METHOD: Active and quiet sleep were differentiated by electroencephalogram (EEG) patterns, eye movements, and respiratory wave patterns; autonomic activity was analyzed using the RR interval of simultaneously recorded electrocardiogram (ECG) signals. Power values (LFa, absolute low frequency; HFa, absolute high frequency), LFa/HFa ratio, and the values of LFn (normalized low frequency) and HFn (normalized high frequency) were obtained. Synchronicity between the power value of HFa and the LFa/HFa ratio during active and quiet sleep was also examined by a new method of chronological demonstration of the power values of HFa and LFa/HFa. RESULTS: We found that LFa, HFa and the LFa/HFa ratio during active sleep were significantly higher than those during quiet sleep in newborns; in adults, on the other hand, the LFa/HFa ratio during rapid eye movement (REM) sleep, considered as active sleep, was significantly higher than that during non-REM sleep, considered as quiet sleep, and HFa values during REM sleep were significantly lower than those during non-REM sleep. LFn during quiet sleep in newborns was significantly lower than that during active sleep. Conversely, HFn during quiet sleep was significantly higher than that during active sleep. Analysis of the four classes of gestational age groups at birth indicated that autonomic nervous activity in a few preterm newborns did not reach the level seen in full-term newborns. Furthermore, the power value of HFa and the LFa/HFa ratio exhibited reverse synchronicity. CONCLUSION: These results indicate that the autonomic patterns in active and quiet sleep of newborns are different from those in REM and non-REM sleep of adults and may be develop to the autonomic patterns in adults, and that parasympathetic activity is dominant during quiet sleep as compared to active sleep from the results of LFn and HFn in newborns. In addition, in some preterm infants, delayed development of the autonomic nervous system can be determined by classifying the autonomic nervous activity pattern of sleep stages.
Description: 博士(医学)・乙第1418号・平成30年3月15日
© 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/10564/3434
ISSN: 03877604
Academic Degrees and number: 24601B1417
Degree-granting date: 2018-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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