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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3427

Title: Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.
Other Titles: 頭頸部癌細胞におけるレスベラトロールのREG III発現誘導効果と癌の進展抑制・治療向上効果
Authors: Mikami, Shinji
Ota, Ichiro
Masui, Takashi
Itaya-Hironaka, Asako
Shobatake, Ryogo
Okamoto, Hideyuki
Takasawa, Shin
Kitahara, Tadashi
Keywords: polyphenol
regenerating gene family
head and neck
squamous cell carcinoma
chemosensitivity
radiosensitivity
Issue Date: Oct-2016
Publisher: Spandidos Publications
Citation: International journal of oncology Vol.49 No.4 p.1553-1560 (2016 Oct)
Abstract: Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.
Description: 博士(医学)・甲第682号・平成30年3月15日
Copyright © Spandidos Publications 2017. All rights reserved.
The Spandidos Publications link is available at " https://doi.org/10.3892/ijo.2016.3664 "
URI: http://hdl.handle.net/10564/3427
ISSN: 10196439
Academic Degrees and number: 24601A682
Degree-granting date: 2018-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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