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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3388

Title: Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease.
Other Titles: 柿由来タンニンは非結核性抗酸菌症(MAC症)のマウスモデルにおいて静菌ならびに抗炎症作用を有する
Authors: Matsumura, Yoko
Kitabatake, Masahiro
Ouji-Sageshima, Noriko
Yasui, Satsuki
Mochida, Naoko
Nakano, Ryuichi
Kasahara, Kei
Tomoda, Koichi
Yano, Hisakazu
Kayano, Shin-ichi
Ito, Toshihiro
Issue Date: 21-Aug-2017
Publisher: Public Library of Science
Citation: PloS one Vol.12 No.8 Article No.e0183489 (2017 Aug)
Abstract: Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection.
Description: 博士(医学)・乙第1408号・平成29年11月24日
Copyright: © 2017 Matsumura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files.
URI: http://hdl.handle.net/10564/3388
ISSN: 19326203
Academic Degrees and number: 24601B1408
Degree-granting date: 2017-11-24
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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