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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3382

Title: Differential therapeutic effects of atomoxetine and methylphenidate in childhood attention deficit/hyperactivity disorder as measured by near-infrared spectroscopy.
Other Titles: 近赤外線スペクトロスコピィを用いた小児期注意欠如・多動症の薬物治療におけるatomoxetineと徐放性methylphenidateの前頭前野に及ぼす治療効果の比較
Authors: Nakanishi, Yoko
Ota, Toyosaku
Iida, Junzo
Yamamuro, Kazuhiko
Kishimoto, Naoko
Okazaki, Kosuke
Kishimoto, Toshifumi
Keywords: Atomoxetine
Attention-deficit/hyperactivity disorder
Functional neuroimaging
Methylphenidate
Near-infrared spectroscopy
Issue Date: 12-May-2017
Publisher: BioMed Central
Citation: Child and adolescent psychiatry and mental health Vol.11 Article No.26 (2017 May)
Abstract: BACKGROUND: The stimulant methylphenidate (MPH) and the nonstimulant atomoxetine (ATX) are the most commonly-prescribed pharmacological treatments for attention deficit/hyperactivity disorder (ADHD). However, the drug-specific mechanism of action on brain function in ADHD patients is not well known. This study examined differences in prefrontal hemodynamic activity between MPH and ATX in children with ADHD as measured by near-infrared spectroscopy (NIRS) using the Stroop color-word task. METHODS: Thirty children with ADHD participated in the present study. We used 24-channel NIRS (ETG-4000) to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received MPH (n = 16) or ATX (n = 14) for 12 weeks. Measurements were conducted every 0.1 s during the Stroop color-word task. We used the ADHD RS-IV-J (Home Version) to evaluate ADHD symptoms. RESULTS: Treatment with either MPH or ATX significantly reduced ADHD symptoms, as measured by the ADHD RS-IV-J, and improved performance on the Stroop color-word task in terms of number of correct words. We found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the ATX condition compared with the values seen at baseline (pre-ATX). In contrast, we found no oxyhemoglobin changes between pre- and post-treatment with MPH. CONCLUSIONS: The present study suggests that MPH and ATX have differential effects on prefrontal hemodynamic activity in children with ADHD.
Description: 博士(医学)・乙第1407号・平成29年9月27日
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
URI: http://hdl.handle.net/10564/3382
ISSN: 17532000
Academic Degrees and number: 24601B1407
Degree-granting date: 2017-09-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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