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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3348

Title: Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer.
Other Titles: ヒト胃癌患者におけるtripartite motif 32の過剰発現は予後不良に関連する
Authors: Ito, Masahiro
Migita, Kazuhiro
Matsumoto, Sohei
Wakatsuki, Kohei
Tanaka, Tetsuya
Kunishige, Tomohiro
Nakade, Hiroshi
Nakatani, Mitsuhiro
Nakajima, Yoshiyuki
Keywords: enzyme 3 ubiquitin ligase
gastric cancer
hematogenous recurrence
prognostic factor
tripartite motif 32
Issue Date: May-2017
Publisher: Spandidos Publications
Citation: Oncology letters Vol.13 No.5 p.3131-3138 (2017 May)
Abstract: Tripartite motif protein (TRIM) 32 belongs to the TRIM family, which is composed of RING finger, B-box and coiled-coil domains. TRIM32 has been reported to function as an enzyme 3 ubiquitin ligase and is overexpressed in numerous types of cancer. The present study evaluated the clinical significance of TRIM32 expression levels in gastric cancer. The current study also investigated the TRIM32 expression levels in 142 patients with gastric cancer using immunohistochemistry and examined its clinical importance and potential as a prognostic marker. Furthermore, the function of TRIM32 was examined in vitro. High TRIM32 expression levels were detected in gastric cancer tissues. The postoperative overall and relapse-free survival rates were significantly reduced in patients with tumors with high levels of TRIM32 expression compared with those with tumors expressing low levels of TRIM32. Tumors expressing high levels of TRIM32 were associated with an increased risk of postoperative recurrence, particularly hematogenous recurrence. Multivariate analysis identified TRIM32 status as an independent prognostic factor. Furthermore, TRIM32 gene silencing induced apoptosis and inhibited the proliferation of gastric cancer cells in vitro. Therefore, TRIM32 expression levels may be of potential prognostic value in gastric cancer.
Description: 博士(医学)・乙第1402号・平成29年6月28日
Copyright © Spandidos Publications 2017. All rights reserved.
発行元が定める登録猶予期間終了の後、本文を登録予定(2017.12)
URI: http://hdl.handle.net/10564/3348
ISSN: 17921074
Academic Degrees and number: 24601B1402
Degree-granting date: 2017-06-28
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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