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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3346

Title: Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer.
Other Titles: ヒト膵癌におけるNectin-4発現の腫瘍増殖、血管新生に対する効果と臨床的意義
Authors: Nishiwada, Satoshi
Sho, Masayuki
Yasuda, Satoshi
Shimada, Keiji
Yamato, Ichiro
Akahori, Takahiro
Kinoshita, Shoichi
Nagai, Minako
Konishi, Noboru
Nakajima, Yoshiyuki
Keywords: Nectin-4
Prognostic factor
Pancreatic cancer
Tumor angiogenesis
Issue Date: 28-Mar-2015
Publisher: BioMed Central
Citation: Journal of experimental & clinical cancer research Vol.34 Article No.30 (2015 Mar)
Abstract: BACKGROUND: Nectin-4 belongs to the nectin family that has diverse physiological and pathological functions in humans. Recent studies have also suggested some roles for Nectin-4 in several human cancers. However, the precise roles and clinical relevance of Nectin-4 in tumors are largely unknown. METHODS: Nectin-4 expression was investigated in 123 patients with pancreatic cancer by immunohistochemistry. Furthermore, we investigated the association of Nectin-4 in pancreatic cancer with tumor proliferation, angiogenesis and immunity by using immunohistochemistry and siRNA interference method. RESULTS: Patients with high Nectin-4 expression had poorer postoperative prognosis than those with low expression. Importantly, multivariate analysis indicated that Nectin-4 expression had a significant independent prognostic value in pancreatic cancer (HR = 1.721, 1.085-2.730; P = 0.021). Tumor Nectin-4 expression was significantly correlated with Ki67 expression. In addition, siRNA-mediated gene silencing of Nectin-4 significantly inhibited the cell proliferation in human pancreatic cancer cells, Capan-2 and BxPC-3. Furthermore, Nectin-4 expression was also positively correlated with VEGF expression and intratumoral microvessel density. However, there were no significant correlations of tumor Nectin-4 expression with tumor-infiltrating T cells. CONCLUSION: Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.
Description: 博士(医学)・乙第1400号・平成29年6月28日
Copyright © Nishiwada et al.; licensee BioMed Central. 2015 : This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
URI: http://hdl.handle.net/10564/3346
ISSN: 03929078
DOI: http://dx.doi.org/10.1186/s13046-015-0144-7
Academic Degrees and number: 24601B1400
Degree-granting date: 2017-06-28
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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