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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3326

Title: Impact of Smoking on Pancreatic Cancer Patients Receiving Current Chemotherapy.
Other Titles: 化学療法を施行した膵癌患者に対する喫煙の影響
Authors: Kawaguchi, Chihiro
Sho, Masayuki
Tanaka, Toshihiro
Akahori, Takahiro
Kinoshita, Shoichi
Nagai, Minako
Yasuda, Satoshi
Nishiwada, Satoshi
Nishiofuku, Hideyuki
Kichikawa, Kimihiko
Nakajima, Yoshiyuki
Keywords: chemotherapy
pancreatic cancer
Issue Date: Oct-2015
Publisher: Wolters Kluwer Health, Inc.
Citation: Pancreas Vol.44 No.7 p.1155-1160 (2015 Oct)
Abstract: OBJECTIVE: Smoking may affect pharmacokinetics of chemotherapeutic agents and hemodynamics of the smokers, thereby influencing adverse events and efficacy of chemotherapy in patients with pancreatic cancer (PC). The aim of this study was to clarify how smoking totally affected patients with PC receiving current chemotherapy. METHODS: We evaluated the impact of smoking status on the performance of chemotherapy and survival in 262 patients with PC including 158 resectable and 104 unresectable PC. RESULTS: There were more male and younger patients in current smokers than in nonsmokers. In unresectable PC, current smokers had more metastatic tumors than locally advanced tumors compared with nonsmokers. In current smokers receiving chemotherapy, the baseline white blood cell count, neutrophil count, and hemoglobin concentration were significantly higher in current smokers than in nonsmokers. Furthermore, grades 3 to 4 neutropenia was observed more often in nonsmokers than smokers. On the other hand, the performance and efficacy of the planned adjuvant chemotherapy were similar between smokers and nonsmokers. More importantly, there was no significant difference in overall prognosis between smokers and nonsmokers receiving chemotherapy. CONCLUSIONS: Smoking status has no significant impact on the efficacy of current chemotherapy for both resectable and unresectable PC.
Description: 博士(医学)・乙第1393号・平成29年3月15日
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
This is a non-final version of an article published in final form in "http://dx.doi.org/10.1097/MPA.0000000000000395"
URI: http://hdl.handle.net/10564/3326
ISSN: 08853177
DOI: http://dx.doi.org/10.1097/MPA.0000000000000395
Academic Degrees and number: 24601B1393
Degree-granting date: 2017-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2016年度

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