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01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.67 No.1,2,3 >

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/3297

タイトル: AKT Plays a Crucial Role in Gastric Cancer.
著者: Luo, Yi
Fujiwara, Rina
Nishiguchi, Yukiko
Kuniyasu, Hiroki
キーワード: Helicobacter pylori
chronic gastritis
発行日: 2016年6月30日
出版者: 奈良医学会
引用: Journal of Nara Medical Association Vol.67 No.1,2,3 p.1-9 (2016.06)
抄録: The AKT protein is involved in the phosphatidylinositol-3 kinase signaling pathway and is a vital regulator of survival. proliferation, and differentiation of various types of cells. Helicobacter pylori induce epithelial cell proliferation and oxidative stress in chronic gastritis. These alterations lead to telomere shortening and resultant telomerase activation. Specifically, AKT is activated by H. pylori-induced inflammation; it subsequently promotes expression of human telomerase reverse transcriptase, which encodes a catalytic subunit of telomerase; and induces telomerase activity, which is an essential process of carcinogenesis. AKT activation is increased in gastric mucosa with carcinogenic properties and is associated with low survival of patients with gastric cancer. These findings suggest that AKT is pivotal in gastric carcinogenesis and progression.
URI: http://hdl.handle.net/10564/3297
ISSN: 13450069
出現コレクション:Vol.67 No.1,2,3


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