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01 奈良県立医科大学 >
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0122 学位請求論文 >
01221 博士論文(医学) >
2016年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/3294
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タイトル: | The unique luminal staining pattern of cytokeratin 5/6 in adenoid cystic carcinoma of the breast may aid in differentiating it from its mimickers. |
その他のタイトル: | 乳腺腺様嚢胞癌においてサイトケラチン5/6の腺腔形成細胞の染色性は類似病変との鑑別に有用である |
著者: | Nakai, Tokiko Ichihara, Shu Kada, Akiko Ito, Noriko Moritani, Suzuko Kawasaki, Tomonori Uchiyama, Tomoko Itami, Hiroe Morita, Kouhei![](/dspace/image/metalink/link_ja.gif) Takano, Masato![](/dspace/image/metalink/link_ja.gif) Takeda, Maiko![](/dspace/image/metalink/link_ja.gif) Hatakeyama, Kinta![](/dspace/image/metalink/link_ja.gif) Ohbayashi, Chiho![](/dspace/image/metalink/link_ja.gif) |
キーワード: | Adenoid cystic carcinoma Collagenous spherulosis Cytokeratin 5/6 Myoepithelial cells Vimentin |
発行日: | 2016年8月 |
出版者: | Springer Nature |
引用: | Virchows Archiv Vol.469 No.2 p.213-222 (2016 Aug) |
抄録: | Adenoid cystic carcinoma (AdCC) of the breast is an uncommon but distinct neoplasm composed of a dual cell population polarized around true glandular (luminal) spaces and pseudolumina. The aim of this study was to clarify whether various immunohistochemical markers (CK7, EMA, CD117, p63, calponin, CD10, S100, CK5/6, CK14, vimentin, and type IV collagen) can distinguish between the two cell types in classical AdCC (n = 14) and in collagenous spherulosis (n = 5). The sensitivity and specificity of these 11 markers to distinguish luminal from abluminal cells were evaluated using a curve created by plotting the true-positive rate (sensitivity) against the false-positive rate (1 - specificity) at threshold settings of 0, 10, 50, and 70 %. The most sensitive and specific markers for luminal cells in AdCC were CK7 and EMA; those for abluminal cells were type IV collagen, p63, and vimentin. CD10 and S100 did not act as abluminal markers in AdCC. CK5/6, one of the basal/myoepithelial markers, was expressed more frequently in luminal than in abluminal cells of AdCC. Thus, CK5/6 immunostaining resulted in a reverse expression pattern, analogous to what we recently documented in clear cells in mammary adenomyoepithelioma. In conclusion, compared with myoepithelial/abluminal cells of normal breast or collagenous spherulosis, the neoplastic abluminal cells of classical AdCC are characterized by enhanced vimentin and attenuated CD10 and S100. Furthermore, the luminal cells of AdCC show a unique aberrant staining pattern for CK5/6 that may aid in the differential diagnosis. |
内容記述: | 博士(医学)・乙第1389号・平成28年11月24日 © Springer-Verlag Berlin Heidelberg 2016 The final publication is available at Springer via http://dx.doi.org/10.1007/s00428-016-1963-4 |
URI: | http://hdl.handle.net/10564/3294 |
ISSN: | 09456317 |
DOI: | http://dx.doi.org/10.1007/s00428-016-1963-4 |
学位授与番号: | 24601B1389 |
学位授与年月日: | 2016-11-24 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2016年度
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