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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3294

Title: The unique luminal staining pattern of cytokeratin 5/6 in adenoid cystic carcinoma of the breast may aid in differentiating it from its mimickers.
Other Titles: 乳腺腺様嚢胞癌においてサイトケラチン5/6の腺腔形成細胞の染色性は類似病変との鑑別に有用である
Authors: Nakai, Tokiko
Ichihara, Shu
Kada, Akiko
Ito, Noriko
Moritani, Suzuko
Kawasaki, Tomonori
Uchiyama, Tomoko
Itami, Hiroe
Morita, Kouhei
Takano, Masato
Takeda, Maiko
Hatakeyama, Kinta
Ohbayashi, Chiho
Keywords: Adenoid cystic carcinoma
Collagenous spherulosis
Cytokeratin 5/6
Myoepithelial cells
Vimentin
Issue Date: Aug-2016
Publisher: Springer Nature
Citation: Virchows Archiv Vol.469 No.2 p.213-222 (2016 Aug)
Abstract: Adenoid cystic carcinoma (AdCC) of the breast is an uncommon but distinct neoplasm composed of a dual cell population polarized around true glandular (luminal) spaces and pseudolumina. The aim of this study was to clarify whether various immunohistochemical markers (CK7, EMA, CD117, p63, calponin, CD10, S100, CK5/6, CK14, vimentin, and type IV collagen) can distinguish between the two cell types in classical AdCC (n = 14) and in collagenous spherulosis (n = 5). The sensitivity and specificity of these 11 markers to distinguish luminal from abluminal cells were evaluated using a curve created by plotting the true-positive rate (sensitivity) against the false-positive rate (1 - specificity) at threshold settings of 0, 10, 50, and 70 %. The most sensitive and specific markers for luminal cells in AdCC were CK7 and EMA; those for abluminal cells were type IV collagen, p63, and vimentin. CD10 and S100 did not act as abluminal markers in AdCC. CK5/6, one of the basal/myoepithelial markers, was expressed more frequently in luminal than in abluminal cells of AdCC. Thus, CK5/6 immunostaining resulted in a reverse expression pattern, analogous to what we recently documented in clear cells in mammary adenomyoepithelioma. In conclusion, compared with myoepithelial/abluminal cells of normal breast or collagenous spherulosis, the neoplastic abluminal cells of classical AdCC are characterized by enhanced vimentin and attenuated CD10 and S100. Furthermore, the luminal cells of AdCC show a unique aberrant staining pattern for CK5/6 that may aid in the differential diagnosis.
Description: 博士(医学)・乙第1389号・平成28年11月24日
© Springer-Verlag Berlin Heidelberg 2016
The final publication is available at Springer via http://dx.doi.org/10.1007/s00428-016-1963-4
URI: http://hdl.handle.net/10564/3294
ISSN: 09456317
Academic Degrees and number: 24601B1389
Degree-granting date: 2016-11-24
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2016年度

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