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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3292

Title: Two-year prognosis after residential treatment for patients with alcohol dependence: three chief guidelines for sobriety in Japan.
Other Titles: アルコール依存症で入院加療二年予後調査 : 日本の伝統的断酒3本柱について
Authors: Cho, Tetsuji
Negoro, Hideki
Saka, Yasuhiro
Morikawa, Masayuki
Kishimoto, Toshifumi
Keywords: alcohol dependence
three chief guidelines for sobriety (3CGS)
disulfiram
self-help group
recovery
Issue Date: 5-Aug-2016
Publisher: Dove Press
Citation: Neuropsychiatric disease and treatment Vol.12 p.1983-1991 (2016 Aug)
Abstract: BACKGROUND: In Japan, the three chief traditional guidelines for sobriety (3CGS) are regular medical checkups, participation in self-help groups, and pharmacotherapy with antidipsotropics. However, the official record of the origins of 3CGS is not clear. The aim of this current study was to assess 3CGS by an examination of the prognosis of patients with alcohol dependence 2 years after their discharge from a residential treatment program. SUBJECTS AND METHODS: The association between subjects' abstinence from alcohol and their regular medical checkups, participation in self-help groups, and treatment with antidipsotropics were prospectively examined. Two years after discharge, the relationship between the 3CGS compliance and abstinence rates was investigated as the primary outcome. In addition, the following were examined as secondary outcomes: the time taken till the first drink after discharge, whether the participants were readmitted to residential treatment, the number of days to readmission, the number of heavy drinking days, and recovery. RESULTS: A total of 98 patients participated. The perfect and partial abstinence rates for patients who followed all the principles of 3CGS were significantly higher than those for patients who followed no guidelines (P<0.05 and P<0.01, respectively). The perfect abstinence rates for patients who had continued attending checkup sessions (P<0.001) and who were taking antidipsotropics (P<0.05) were significantly higher than those for patients who did not follow these components of 3CGS. However, the perfect abstinence rates were not higher for patients who had continued to participate in self-help groups. In addition, the perfect abstinence rate was statistically associated with regular medical checkups (adjusted odds ratio =5.33, 95% confidence interval =1.35-21.0) and participation in self-help groups (adjusted odds ratio =3.79, 95% confidence interval =1.17-12.3). CONCLUSION: This study, reports the effectiveness of 3CGS for the first time. The recovery rate of alcoholics 2 years after discharge from residential treatment was examined. However, due to the chronic nature of alcoholism, further studies are required to investigate the efficacy of 3CGS beyond 2 years.
Description: 博士(医学)・乙第1387号・平成28年11月24日
© 2016 Cho et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
The definitive version is available at " http://dx.doi.org/10.2147/NDT.S111230 "
URI: http://hdl.handle.net/10564/3292
ISSN: 11766328
Academic Degrees and number: 24601B1387
Degree-granting date: 2016-11-24
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2016年度

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