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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.59 No.1-2 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/329
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| Title: | PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH OVARJAN TERATOMA: CLINICAL PICTURES AND N-METHYL-D-ASPARTATE RECEPTOR ANTIBODIES |
| Authors: | Kataoka, Hiroshi
Ueno, Satoshi |
| Keywords: | paraneoplastic encephalitis
ovarlan teratoma
NMDAR |
| Issue Date: | 30-Apr-2008 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.59 No.1-2 p.25-32 |
| Abstract: | Background: Recently, a new category of paraneoplastic encephalitis
associated with ovarian teratoma has been described and associates with antibodies to
NRI/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR).
Methods: We describe clinical pictures of 26 patients with ovarian teratoma-associated
encephalitis (OTE) and the presence of NMDAR antibodies.
Results: Clinically, OTE was characterized by the development of acute prominent psy-
chiatric symptoms (25 of 26 patients), seizures (19 of 26 patients), central hypoventilation
(18 of 26 patients) and involuntary movements (19 of 26 patients). Ventilatory support
was required for 84.5 ± 71.8 days on average. The white blood cell count in cerebrospinal
fluid was 50.0 ± 56.6/mm3. Twelve patients showed abnormalities on cranial MRI,
involving areas such as the temporal regions (seven patients) or brainstem (four
patients). In addition to tumor resection, twenty patients received some type of
immunotherapy. Twenty-three patients with OTE had neurological improvement,
including 14 with full recovery. Immunocytochemical studies showed that cells
expressing NR1/NR2 heteromers reacted strongly with the CSF of patients with OTE.
Conclusions: Neurologists must be aware of the syndrome described above and
evaluate antibodies to NR1/NR2B heteromers of the NMDAR. Detection of these
antibodies should prompt the search for an ovarian teratoma and the administration of
immunotherapy. |
| URI: | http://hdl.handle.net/10564/329 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.59 No.1-2
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| 25-32p.PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH OVARJAN TERATOMA.pdf | | 3238Kb | Adobe PDF | View/Open |
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