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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3259

Title: Adjuvant Hepatic Arterial Infusion Chemotherapy After Resection for Pancreatic Cancer Using Coaxial Catheter-Port System Compared with Conventional System.
Other Titles: 膵癌術後予防肝動注におけるリザーバー留置術の検討 : 従来法とcoaxialシステムの比較
Authors: Hashimoto, Aya
Tanaka, Toshihiro
Sho, Masayuki
Nishiofuku, Hideyuki
Masada, Tetsuya
Sato, Takeshi
Marugami, Nagaaki
Anai, Hiroshi
Sakaguchi, Hiroshi
Kanno, Masatoshi
Tamamoto, Tetsuro
Hasegawa, Masatoshi
Nakajima, Yoshiyuki
Kichikawa, Kimihiko
Keywords: Arterial infusion chemotherapy
Pancreatic cancer
Liver metastases
Issue Date: Jun-2016
Publisher: Springer Verlag
Citation: Cardiovascular and interventional radiology Vol. 39 No.6 p.831-839 (2016 Jun)
Abstract: PURPOSE: Previous reports have shown the effectiveness of adjuvant hepatic arterial infusion chemotherapy (HAIC) in pancreatic cancer. However, percutaneous catheter placement is technically difficult after pancreatic surgery. The purpose of this study was to evaluate the feasibility and outcome of HAIC using a coaxial technique compared with conventional technique for postoperative pancreatic cancer. MATERIALS AND METHODS: 93 consecutive patients who received percutaneous catheter-port system placement after pancreatectomy were enrolled. In 58 patients from March 2006 to August 2010 (Group A), a conventional technique with a 5-Fr indwelling catheter was used and in 35 patients from September 2010 to September 2012 (Group B), a coaxial technique with a 2.7-Fr coaxial catheter was used. RESULTS: The overall technical success rates were 97.1 % in Group B and 86.2 % in Group A. In cases with arterial tortuousness and stenosis, the success rate was significantly higher in Group B (91.7 vs. 53.8 %; P = 0.046). Fluoroscopic and total procedure times were significantly shorter in Group B: 14.7 versus 26.7 min (P = 0.001) and 64.8 versus 80.7 min (P = 0.0051), respectively. No differences were seen in the complication rate. The 1 year liver metastasis rates were 9.9 % using the conventional system and 9.1 % using the coaxial system (P = 0.678). The overall median survival time was 44 months. There was no difference in the survival period between two systems (P = 0.312). CONCLUSIONS: The coaxial technique is useful for catheter placement after pancreatectomy, achieving a high success rate and reducing fluoroscopic and procedure times, while maintaining the safety and efficacy for adjuvant HAIC in pancreatic cancer.
Description: 博士(医学)・乙第1380号・平成28年7月8日
© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2016
The final publication is available at Springer via http://dx.doi.org/10.1007/s00270-016-1292-7
URI: http://hdl.handle.net/10564/3259
ISSN: 01741551
Academic Degrees and number: 24601B1380
Degree-granting date: 2016-07-08
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2016年度

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