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01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.58 No.5-6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/324
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Title: | 神経疾患とメタボリックシンドローム : 通院患者における合併頻度 |
Other Titles: | ASSOCIATION OF NEUROLOGICAL DISEASES WITH METABOLIC SYNDROME AMONG OUT-PATIENTS |
Authors: | 上野, 聡 降矢, 芳子 杉江, 和馬 川原, 誠 形岡, 博史 斉藤, こずえ 桐山, 敬生 木下, 聡子 平野, 牧人 |
Keywords: | metabolic syndrome visceral fat neurological diseases |
Issue Date: | 31-Dec-2007 |
Publisher: | 奈良医学会 奈良県立医科大学 |
Citation: | Journal of Nara Medical Association Vol.58 No.5-6 p.189-196 |
Abstract: | Background and Objective: Metabolic syndrome (MetS) is highly prevalent
in Japan; however, most previous surveys have studied only adults able to engage fully
in normal daily activities, after excluding persons with diseases or disabilities. Recently,
lifestyle-related risk factors have been strongly linked to a number of major diseases. In
particular, the incidence of atherosclerotic vascular diseases associated with MetS has
increased markedly, and this trend is projected to continue. We focused on the prevalence
of MetS among out-patients with neurological diseases.
Patients and methods: The subjects for this hospital-based study were 713 out-patients
with various neurological diseases (329 men, mean age 65.2 ± 14.5 yr, age range 40-78 yr,
and 384 women, mean age 64.6 ± 15.3 yr, age range 40-88 yr) who presented at the
Department of Neurology, Nara Medical University Hospital. A total of 120 patients had
cerebral infarction, 102 Parkinson's disease, 32 spinal spondylosis, 30 headache, 32
myositis, and the rest various other neurological diseases. MetS was diagnosed according
to the criteria proposed by The Japanese Society of Internal Medicine in 2005. The cutoff
values for waist circumference (WC) were greater than 85 cm in men and 90 cm in
women. A diagnosis of MetS additionally required two or more of the following: a serum
triglyceride level (TG) of at least 150 mg/dl and/or a high-density lipoprotein cholesterol
level (HDLC) of less than 40 mg/dl; a blood pressure (BP) of greater than 130/85; or a
fasting plasma glucose level (FPG) of greater than 110 mg/dl. Visceral fat accumulation
was measured by abdominal CT scanning (N2systern, K.K., Japan).
Results: WC positively correlated with visceral fat area as determined by CT
scanning. WC also positively correlated with TG in both sexes and FBS in women, but
negatively correlated with HDL-C in both sexes. The mean prevalence of MetS among
subjects 40 to 70 years of age was 25.1% in men and 12.6% in women. To assess the
incidence of MetS in the absence of cerebrovascular disease (CVD), we performed a
subgroup analysis of patients with and without CVD. The risk of MetS was similar in out-
patients without CVD and those with CVD. The prevalence of Pre MetS (defined as WC
plus one risk factor) plus MetS was 50% in men and 20% in women. The prevalence of
MetS in outpatients with neurological diseases was similar to that in the general
population.
Conclusion: The risk of atherosclerotic diseases in out-patients with neurological
diseases is similar to that in the general population, potentially increasing the risk of
unfavorable outcomes. The recognition and management of MetS represents an important
challenge for physicians and other healthcare professionals. Strategies aimed at reducing
risk factors for MetS are urgently required. |
URI: | http://hdl.handle.net/10564/324 |
ISSN: | 13450069 |
Appears in Collections: | Vol.58 No.5-6
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