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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3177

Title: Differential patterns of blood oxygenation in the prefrontal cortex between patients with methamphetamine-induced psychosis and schizophrenia.
Other Titles: 近赤外線スペクトロスコピィを用いた覚醒剤精神病と統合失調症の鑑別
Authors: Yamamuro, Kazuhiko
Makinodan, Manabu
Kimoto, Sohei
Kishimoto, Naoko
Morimoto, Tsubasa
Toritsuka, Michihiro
Matsuoka, Kiwamu
Takebayashi, Yoshihiro
Takata, Tomoyo
Takahashi, Masato
Tanimura, Yoshinori
Nishihata, Yosuke
Matsuda, Yasuhiro
Ota, Toyosaku
Yoshino, Hiroki
Iida, Junzo
Kishimoto, Toshifumi
Issue Date: Jun-2015
Publisher: Nature Publishing Group
Citation: Scientific reports Vol.5 p.12107(Article number) (2015.06)
Abstract: Despite some slight differences in symptomatology, differential diagnosis of methamphetamine-induced psychosis (MAP) versus schizophrenia can be challenging because both disorders present a large overlap in their clinical symptoms. However, a recent study has shown that near-infrared spectroscopy (NIRS) performed during a cognitive task can be a powerful tool to differentiate between these two disorders. Here, we evaluated verbal fluency task performance during NIRS in 15 patients diagnosed with MAP and 19 with schizophrenia matched for age and sex. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhaemoglobin every 0.1 s during the task. For each patient, the neurocognitive function and clinical psychopathology were evaluated using the Positive and Negative Symptom Scale (PANSS), and the Brief Assessment of Cognition in Schizophrenia (BACS). Oxyhaemoglobin changes in the prefrontal cortex were significantly higher in the MAP group compared to those in the schizophrenia group, particularly in the right dorsolateral prefrontal cortex. In contrast, we found no significant difference in PANSS and BACS scores. Our findings suggest that NIRS measurement could be applied to differentiate patients with MAP from those with schizophrenia, even in cases where clinical symptoms are similar.
Description: 博士(医学)・甲第645号・平成28年3月15日
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
URI: http://hdl.handle.net/10564/3177
ISSN: 20452322
Academic Degrees and number: 24601A645
Degree-granting date: 2016-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2015年度

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