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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3170

Title: Selective induction of antimicrobial peptides from keratinocytes by staphylococcal bacteria.
Other Titles: ブドウ球菌の表皮ケラチノサイトからの選択的抗菌ペプチドの誘導
Authors: Ommori, Rie
Ouji, Noriko
Mizuno, Fumiko
Kita, Eiji
Ikada, Yoshito
Asada, Hideo
Keywords: Keratinocytes
Human β-defensin
Staphylococcus aureus
Staphylococcus epidermidis
Toll-like receptor 2
Issue Date: Mar-2013
Publisher: Elsevier
Citation: Microbial pathogenesis Vol.56 p.35-39(2013.03)
Abstract: Staphylococcus aureus (S. aureus) is one of the most clinically important inflammation-inducing pathogens, while Staphylococcus epidermidis (S. epidermidis) is nonpathogenic and hardly causes inflammation on skin. β-defensins, antimicrobial peptides, are secreted from keratinocytes constitutively or upon induction by various microorganisms. However, the difference between S. aureus and S. epidermidis is still unclear in terms of their influences on the production of β-defensins. In this study, we focused on the influences of S. aureus and S. epidermidis on the keratinocyte innate immune response. Pathogenic S. aureus mainly induced human β-defensin (hBD) 1 and hBD3, but not hBD2, and nonpathogenic S. epidermidis mainly induced hBD2 from human keratinocytes. Molecular weight fractions of >10 kDa prepared from S. aureus supernatants induced the production of hBD1 and hBD3. On the other hand, molecular weight fraction of >100 kDa prepared from S. epidermidis supernatants induced the production of hBD2.Furthermore, the secreted products of S. epidermidis used the toll-like receptor (TLR) 2 pathway in the induction of hBD2 production. The secreted products of S. aureus and S. epidermidis differentially induced subtypes of hBD through different receptors, which may be associated with the difference in virulence between these two bacteria.
Description: 博士(医学)・甲第643号・平成28年3月15日
Copyright © 2012 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10564/3170
ISSN: 08824010
Academic Degrees and number: 24601A643
Degree-granting date: 2016-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2015年度

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