GINMU >
01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.66 No.1-2 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/3150
|
タイトル: | エライジン酸の5-fluorouracil抗腫瘍効果に与える影響 |
その他のタイトル: | EFFECT OF ELAIDIC ACID ON ANTI-TUMORAL EFFECT OF 5-FLUOROURACIL |
著者: | 北吉, 美沙穂 田邊, 絵里子 羅, 奕![](/dspace/image/metalink/link_ja.gif) 國安, 弘基![](/dspace/image/metalink/link_ja.gif) |
キーワード: | Linoleic Acid トランス脂肪酸 抗腫瘍剤効力検定 腫瘍細胞系 動物実験 腫瘍幹細胞 RT-PCR法 Aldehyde Dehydrogenase ノンパラメトリック法 |
発行日: | 2015年4月30日 |
出版者: | 奈良医学会 奈良県立医科大学 |
引用: | Journal of Nara Medical Association Vol.66 No.1-2 p.7-13 |
抄録: | We studied the effects of elaidic acid (EA) has on the anti-tumor effect of 5-fluorouracil (FU). Examining the 5-FU sensitivity in mouse lung cancer cell line LL2, and mouse colorectal cancer cell lines
CT26 and CMT93, CMT93 showed low sensitivity. The increased growth inhibitory effects in CT26, CMT93, and LL2 cells were 1.0-, 1.2-, and 1.1-times, respectively, on concurrent treatment with EA at an apoptosis-inducing concentration and 5-FU at a concentration of IC50. On examining aldehyde dehydrogenase (ALDH) activity changes in the cancer stem cells in this case, it was found to have been increased 3.8-fold by simultaneous treatment with 5-FU and EA in CT26 and LL2 cells, but 1.5-fold in CMT93 cells. In addition, considering the expression of nucleostemin as a stem cell marker, in simultaneous treatment with 5-FU
and EA, and treatment with EA alone, the expression was increased in CT26 and LL2 cells, whereas the expression level did not change in CMT93 cells. The foregoing suggests that, rather than altering the 5-FU
sensitivity of cancer cells, EA might promote the survival of cancer stem cells. The results suggest that the content of the diet during chemotherapy is a relevant issue. |
URI: | http://hdl.handle.net/10564/3150 |
ISSN: | 13450069 |
出現コレクション: | Vol.66 No.1-2
|
このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。
|