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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3109

Title: Phototherapy with blue and green mixed-light is as effective against unconjugated jaundice as blue light and reduces oxidative stress in the Gunn rat model.
Other Titles: 高非抱合型ビリルビン血症に対する光療法における青色と緑色光を混合した光療法は青色光単色と治療効果は同等であり、かつ光酸化ストレス反応を軽減する : Gunn ratモデルにおける検討
Authors: Uchida, Yumiko
Morimoto, Yukihiro
Uchiike, Takao
Kamamoto, Tomoyuki :4/0000339
Hayashi, Tamaki
Arai, Ikuyo
Nishikubo, Toshiya
Takahashi, Yukihiro
Keywords: Side effects
Light emitting diode
Unbound bilirubin
Issue Date: Jul-2015
Publisher: Elsevier
Citation: Early human development Vol.91 No.7 p.381–385 (2015.07)
Abstract: OBJECTIVE:Phototherapy using blue light-emitting diodes (LED) is effective against neonatal jaundice. However, green light phototherapy also reduces unconjugated jaundice. We aimed to determine whether mixed blue and green light can relieve jaundice with minimal oxidative stress as effectively as either blue or green light alone in a rat model. METHODS:Gunn rats were exposed to phototherapy with blue (420-520 nm), filtered blue (FB; 440-520 nm without<440-nm wavelengths, FB50 (half the irradiance of filtered blue), mixed (filtered 50% blue and 50% green), and green (490-590 nm) LED irradiation for 24h. The effects of phototherapy are expressed as ratios of serum total (TB) and unbound (UB) bilirubin before and after exposure to each LED. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was measured by HPLC before and after exposure to each LED to determine photo-oxidative stress. RESULTS:Values < 1.00 indicate effective phototherapy. The ratios of TB and UB were decreased to 0.85, 0.89, 1.07, 0.90, and 1.04, and 0.85, 0.94, 0.93, 0.89, and 1.09 after exposure to blue, filtered blue, FB50, and filtered blue mixed with green LED, respectively. In contrast, urinary 8-OHdG increased to 2.03, 1.25, 0.96, 1.36, 1.31, and 1.23 after exposure to blue, filtered blue, FB50, mixed, green LED, and control, indicating side-effects (> 1.00), respectively. CONCLUSIONS:Blue plus green phototherapy is as effective as blue phototherapy and it attenuates irradiation-induced oxidative stress. PRACTICE IMPLICATIONS:Combined blue and green spectra might be effective against neonatal hyperbilirubinemia.
Description: 博士(医学)・乙第1371号・平成27年11月27日
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/10564/3109
Academic Degrees and number: 24601B1371
Degree-granting date: 2015-11-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2015年度

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