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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3107

Title: Estimated functional renal parenchymal volume predicts the split renal function following renal surgery.
Other Titles: 機能的腎体積測定による術後分腎機能評価の検討
Authors: Mibu, Hisakazu
Tanaka, Nobumichi
Hosokawa, Yukinari
Kumamoto, Hiromi
Marugami, Nagaaki
Hirao, Yoshihiko
Fujimoto, Kiyohide
Keywords: Renal function
Renal volume
Nephrectomy
Nephron-sparing surgery
3-D image reconstruction
Issue Date: Oct-2015
Publisher: Springer International
Citation: World journal of urology Vol.33 No.10 p.1571-1577 (2015.10)
Abstract: PURPOSE:The change in functional renal volume (FRV) has an absolute influence on renal function after nephrectomy (Nx) or nephron-sparing surgery (NSS). In this study, we prospectively examined whether the postoperative renal function following Nx and NSS could be accurately predicted and assessed the reproducibility of our newly developed 3-D image reconstruction system (Kashihara) to measure the FRV. METHODS:We enrolled 98 patients who underwent Nx and 41 patients who underwent NSS from April 2006 to September 2009 to predict postoperative FRV and renal function. FRV was measured before and after (1 month and 1 year) renal surgery. The postoperative estimated glomerular filtration rate (eGFR) was predicted from the preoperative eGFR calculated from the serum creatinine (sCr) level and the ratio of the postoperative/preoperative FRV. To assess the reproducibility and accuracy of our newly developed 3-dimensional (3-D) image reconstruction system, FRV was measured by five examiners using images obtained by CT (five cases) and MRI (five cases). RESULTS:Significant correlation was found both for FRV and for renal function between the predictive values and the actually measured values at 1 month and 1 year after surgery, not only in the Nx group, but also in the NSS group. The accuracy and reproducibility could be confirmed both with CT and MRI studies. CONCLUSIONS:The postoperative FRV and renal function could be predicted preoperatively using a 3-D image reconstructive system, preoperative routine diagnostic imaging, and preoperative sCr level.
Description: 博士(医学)・乙第1369号・平成27年11月27日
© Springer-Verlag Berlin Heidelberg 2015
The final publication is available at Springer via http://dx.doi.org/10.1007/s00345-014-1470-7
URI: http://hdl.handle.net/10564/3107
ISSN: 07244983
Academic Degrees and number: 24601B1369
Degree-granting date: 2015-11-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2015年度

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01_乙1369本文の要旨.pdf乙1369本文の要旨299.78 kBAdobe PDFView/Open
02_乙1369審査要旨.pdf乙1369審査要旨318.27 kBAdobe PDFView/Open
03_乙1369本文.pdf乙1369本文317.31 kBAdobe PDFView/Open
04_乙1369Figure_1-2.pdf乙1369Figure 1-2241.58 kBAdobe PDFView/Open
05_乙1369Table_1-4.pdf乙1369Table 1-4449.76 kBAdobe PDFView/Open

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