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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3077

Title: HVEM expression contributes to tumor progression and prognosis in human colorectal cancer.
Other Titles: ヒト大腸癌におけるHVEM発現は腫瘍の進行と予後に影響する
Authors: Inoue, Takashi
Sho, Masayuki
Yasuda, Satoshi
Nishiwada, Satoshi
Nakamura, Shinji
Ueda, Takeshi
Nishigori, Naoto
Kawasaki, Keijiro
Obara, Shinsaku
Nakamoto, Takayuki
Koyama, Fumikazu
Fujii, Hisao
Nakajima, Yoshiyuki
Keywords: Colorectal cancer
tumor immunity
Issue Date: Mar-2015
Publisher: The International Institute of Anticancer Research
Citation: Anticancer research Vol.35 No.3 p.1361-1367(2015 Mar)
Abstract: Background: Herpesvirus entry mediator (HVEM) has been recently suggested to play certain roles in cancer biology. We examined HVEM expression in human colorectal cancer (CRC) to reveal its clinical importance. Materials and Methods: Immunohistochemical staining was carried-out in normal epithelium, benign and malignant lesions. Results: While intense HVEM expression was not observed in normal epithelium and hyperplastic polyps, 24% of adenoma and more than half of CRCs had high HVEM expression. In 234 CRCs, HVEM expression was significantly associated with tumor status and pathological stage. Patients with high HVEM expression had a significantly poorer prognosis than those with low expression. Importantly, HVEM status had an independent prognostic value in CRC. Furthermore, HVEM status was inversely corrected with the presence of tumor-infiltrating T-cells. Conclusion: HVEM may play a critical role in tumor progression and immune evasion, and may also be a novel prognostic marker and potential therapeutic target in human CRC.
Description: 博士(医学)・乙第1363号・平成27年7月31日
発行元の規定により、本文の登録不可。本文は以下のURLを参照 "http://ar.iiarjournals.org/content/35/3/1361.abstract" (※全文閲覧は学内限定)
URI: http://hdl.handle.net/10564/3077
ISSN: 02507005
Academic Degrees and number: 24601B1363
Degree-granting date: 2015-07-31
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2015年度

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