温阻血およびサイクロスポリンAによるラット障害腎に対する心房性ナトリウム利尿ペプチド投与による影響

Abstract

The nephrotoxicity of Cyclosporine A (CYA) is a serious problem, and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation. On the other hand, the newly described atrial natriuretic peptide (ANP) hormonal system in both humans and animals appears to play an important role in sodium and water excretion. In study 1, the effect of recombinant-ANP (r-ANP) on warm ischemic (WI) damaged kidney was examined in six experimental groups. In study 2, the effects of r-ANP on kidneys damaged by WI followd by CYA administration, which is a similar condition in renal transplantation, were examined in four experimental groups. Consequently, the efficiency of r-ANP on renal function which was damaged by CYA and WI was shown to be verifiable.