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01121 Journal of Nara Medical Association >
Vol.46 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3008

Title: 腎不全におけるエンドセリンの検討
Other Titles: Examination of Endothelin in Renal Failure.
Authors: 米田, 龍生
Keywords: hemodialysis
renal transpantation
warm ischemia
Issue Date: 31-Dec-1995
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.46 No.6 p.665-674
Abstract: The role of Endothelin (ET) in renal failure was evaluated by experimental study using rats (study 1) and clinical study (study 2). In study 1, the change of plasma ET level in renal failure was evaluated in two groups of rats. Group 1 consists of sham operation for left kidney and right nephrectomy, and group 2 consists of 60 minutes warm ischemic damaged left kidney and right nephrectomy. In group 2, plasma ET level increased and was followed with the renal insufficiency. In study 2, the comparison of plasma ET level between the chronic renal failure patients treated with hemodialysis (HD) and those treated with renal transplantation (Tx) was demonstrated. In transplanted patients, periodical change of plasma ET level after renal transplantation was demonstrated. The plasma ET level in HD patients is significantly higher than that of Tx patients. The change in plasma ET level corresponded to renal function. In Tx patients, plasma ET level decreased periodically, followed by the improving of renal function. The results of this study suggest that measurement of plasma ET level is useful as a marker of renal function.
URI: http://hdl.handle.net/10564/3008
ISSN: 04695550
Appears in Collections:Vol.46 No.6

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