冠動脈壁におけるAdvanced Glycosylation Endproducts(AGEs)の免疫組織化学的検討

Abstract

Advanced glycosylation endproducts (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from non-insulin dependent diabetic and nondiabetic patients. In the case of diabetes, the incidence of AGEs reactivity is higher in the older group than in the younger group. In the case of nondiabetes, however, there is no difference in the incidence of AGEs reactivity between the two groups. Duration of diabetes mellitus is significantly longer in the AGEs positive group than in the negative group. On the other hand, there is no diffesence in HbA₁c between the AGEs positive and negative groups. Incidence of coronary calcification and degree of coronary stenosis is higher in the AGEs positive group than in the negative group. These data support the role of advanced glycosylation in progressive coronary calcification and coronary stenosis associated with diabetes mellitus.