ヌードマウス可移植性ヒト胃癌および食道癌株における血管新生阻害剤TNP-470の抗腫療効果に関する研究

Abstract

Recently angiogenesis is thought to be necessary for the growth and metastasis of solid tumors. Several anti-angiogenetic compounds which suppress the growth and metastasis of solid tumors have been developed. TNP-470 (o-chloroacetyl-carbamoyl fumagillol), an anti-angiogenetic compound, strongly suppresses the growth of epithelial cells. We determined the effects of TNP-470 alone and in combination with hyperthermia, CDDP or radiation on human gastric and esophageal cancer subcutaneously inoculated into nude mice. In addition, we investigated the effect of TNP-470 on an experimental liver metastasis model using human gastric cancer transplanted into nude mice. The results of experiments using human gastric and esophageal cancer subcutaneously inoculated into nude mice are as follows : 1) TNP-470 alone suppressed the growth of both gastric and esophageal cancer, 2) combination treatment of TNP-470 with hyperthemia suppressed the growth of both gastric and esophageal cancer more strongly than either alone, and 3) it was more effective than the combination treatment of TNP-470 with CDDP or radiation. This study of experimental liver metastasis model demonstrated that TNP-470 alone did not suppress liver metastasis.