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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2976

Title: [18F]fluoro-2-deoxyglucose-positron emission tomography for the assessment of histopathological response after preoperative chemoradiotherapy in advanced oral squamous cell carcinoma.
Other Titles: [18F]fluoro-2-deoxyglucose-positron emission tomography を用いた進行口腔扁平上皮癌における術前化学放射線療法による治療効果判定の検討
Authors: Shimomura, Hiroyuki
Sasahira, Tomonori
Yamanaka, Yasutsugu
Kurihara, Miyako
Imai, Yuichiro
Tamaki, Shigehiro
Yamakawa, Nobuhiro
Shirone, Norihisa
Hasegawa, Masatoshi
Kuniyasu, Hiroki
Kirita, Tadaaki
Keywords: Oral squamous cell carcinoma
FDG-PET
Standardized uptake value
Ki-67
HIF-1α
Chemoradiotherapy
Issue Date: 19-Jun-2014
Publisher: Springer / Japan Society of Clinical Oncology
Citation: International journal of clinical oncology [Epub ahead of print] doi:10.1007/s10147-014-0711-5
Abstract: BACKGROUND: [18F]fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) is widely used to evaluate tumor metabolic activity. The aim of this study was to evaluate the usefulness of FDG-PET in assessing the histopathological response to preoperative concurrent chemoradiotherapy (CRT) in patients with oral squamous cell carcinoma (OSCC). METHODS: Forty-five patients with resectable advanced OSCC who had received preoperative CRT followed by tumor ablative surgery between January 2004 and December 2011 were included in the study. All patients underwent FDG-PET before and after preoperative CRT. The maximum standardized uptake value (SUVmax) before (pre-SUV) and after preoperative CRT (post-SUV) and the SUVmax reduction rate (ΔSUV %) were used to evaluate the response to preoperative CRT. Correlations among SUVmax, histopathological response, and expression of cancer antigen Ki-67 and hypoxia-inducible factor-1α (HIF-1α) were analyzed. RESULTS: Preoperative CRT significantly reduced intratumoral FDG uptake (P < 0.001). The pre-SUV and post-SUV were significantly lower in patients with a pathological complete response (pCR) than in those with a non-pCR (pre-SUV P = 0.037; post-SUV P = 0.001). ΔSUV % was higher in patients with pCR than in those with non-pCR (P = 0.029). The pre-SUV was significantly correlated with Ki-67 and HIF-1α expression in pretreatment biopsy specimens (Ki-67 P = 0.046, R = 0.292; HIF-1α P = 0.007, R = 0.385). The expression of both Ki-67 and HIF-1α was significantly lower in patients with pCR than in those with non-pCR (Ki-67 P < 0.001; HIF-1α P < 0.001). CONCLUSIONS: Low pre-SUV and post-SUV and high ΔSUV % may predict a good histopathological response to preoperative CRT. Ki-67 and HIF-1α expression in pretreatment biopsy specimens were predictors of histopathological response to preoperative CRT.
Description: 博士(医学)・乙第1357号・平成27年3月16日
© Springer International Publishing AG, Part of Springer Science+Business Media
© Japan Society of Clinical Oncology 2014
URI: http://hdl.handle.net/10564/2976
ISSN: 13419625
Academic Degrees and number: 24601B1357
Degree-granting date: 2015-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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