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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2972

Title: Risk factors for the development of gastric mucosal lesions in rheumatoid arthritis patients receiving long-term nonsteroidal anti-inflammatory drug therapy and the efficacy of famotidine obtained from the FORCE study.
Other Titles: 関節リウマチ(RA)患者のNSAIDs長期投与における胃粘膜障害発生因子ならびにファモチジンの治療効果に関する検討
Authors: Kobata, Yasunori
Yajima, Hiroshi
Yamao, Junichi
Tanaka, Yasuhito
Fukui, Hiroshi
Takakura, Yoshinori
Keywords: NSAID
Rheumatoid arthritis
Mucosal lesion
Issue Date: Dec-2009
Publisher: Japan Rheumatism Association / Springer
Citation: Modern rheumatology Vol.19 No.6 p.629-636
Abstract: The objective of this study was to investigate the prevalence of gastric mucosal injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatoid arthritis (RA). Upper gastrointestinal endoscopy was performed on 100 RA patients treated with NSAIDs. Patient factors potentially contributing to the development of NSAID-induced gastric mucosal injury were identified by logistic regression analysis; gastric mucosal injury and ulcers were used as objective variables. Gastric mucosal injury was detected in 62 of 100 patients, and eight of these patients had ulcers. Previous history of ulcers, lifestyle, NSAID dosage, and body mass index were associated with the development of gastric mucosal injury, and the use of diclofenac and steroid dose were associated with the development of ulcers. Disease-modifying antirheumatic drugs (DMARDs) did not appear to influence the risk of NSAID-induced gastric mucosal injury. RA patients treated for long periods with NSAIDs for RA symptoms should be controlled with DMARDs, without consideration of increased doses of steroids, in terms of risk for NSAID-induced gastric mucosal injury. Simultaneously, concomitant use of histamine-2 receptor antagonists (H2RA) such as famotidine should be considered.
Description: 博士(医学)・乙第1354号・平成27年3月16日
© Japan College of Rheumatology 2009
© Springer International Publishing AG, Part of Springer Science+Business Media
URI: http://hdl.handle.net/10564/2972
ISSN: 14397595
Academic Degrees and number: 24601B1354
Degree-granting date: 2015-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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