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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2970

Title: Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris.
Other Titles: 大腿骨頭靭帯の組織学的および分子学的特性に関する研究
Authors: Shinohara, Yasushi
Kumai, Tsukasa
Higashiyama, Ichiro
Hayashi, Koji
Matsuda, Takenori
Tanaka, Yasuhito
Takakura, Yoshinoi
Keywords: enthesis
stress deprivation
ligament rupture
Issue Date: Aug-2014
Publisher: Wiley
Citation: Scandinavian journal of medicine & science in sports Vol.24 No.4, p.e245-e253
Abstract: The ligamentum capitis femoris (LCF) has increased in clinical significance through the development of hip arthroscopy. The histological pathologies and molecular composition of the femoral attachment of the LCF and the degeneration caused by LCF disruption were investigated in the human hip joint. Twenty-four LCFs were retrieved at surgery for femoral neck fracture (age range: 63–87 years). In the “intact” (i.e., intact throughout its length, n = 12) group, the attachment consisted of rich fibrocartilage. Fibrocartilage cells were present in the midsubstance. In contrast, the construction of the attachment in the “disrupted” (i.e., ligament no longer attached to the femoral head, n = 12) group had disappeared. The attachment in the disrupted group was not labeled for type II collagen or aggrecan, while that in the intact group was labeled for types I, II and III collagen, chondroitin 4-sulfate, chondroitin 6-sulfate, aggrecan, and versican. The percentage of single-stranded DNA-positive chondrocytes was significantly higher in the disrupted group than in the intact group. We conclude that the femoral attachment of the LCF has a characteristic fibrocartilaginous structure that is likely to adjust to the mechanical load, and suggest that its degeneration is advanced by disruption and should be regarded as a clinical pathology.
Description: 博士(医学)・乙第1353号・平成27年3月16日
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
URI: http://hdl.handle.net/10564/2970
ISSN: 09057188
Academic Degrees and number: 24601B1353
Degree-granting date: 2015-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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