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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2963

Title: Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study.
Other Titles: 心臓血管外科領域におけるゼラチンシートの止血効果、癒着防止効果の検討
Authors: Hu, Yinghao
Yamashita, Keigo
Tabayashi, Nobuoki
Abe, Takehisa
Hayata, Yoshihiro
Hirose, Tomoaki
Hiraga, Shun
Tojo, Takashi
Suzuki, Shuko
Ikada, Yoshito
Taniguchi, Shigeki
Keywords: gelatin
fibrin glue
surgical sealant
anti-adhesion
postoperative adhesions
Issue Date: 9-Sep-2014
Publisher: IOS press
Citation: Bio-medical materials and engineering in press (2014 September 9)
Abstract: BACKGROUND:The bi1ayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE:To examine the feasibility of gelatin sealing sheets using a canine aterial hemorrhage mode1. METHODS:In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in rats. For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of dogs were pricked with syringe needle to make as mall hole, and a gelatin(i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop bleeding (n=8). After discontinuation of the bleeding, the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS:From the degradation study, 4h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, bleeding from the needle hole on canine femoral arteries was effectively stopped. Postoperative adhesions and inflammation at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS:The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing postoperative adhesions.
Description: 博士(医学)・甲第632号・平成27年3月16日
Copyright ©2015 IOS Press
URI: http://hdl.handle.net/10564/2963
ISSN: 09592989
Academic Degrees and number: 24601A632
Degree-granting date: 2015-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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