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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2937

Title: Expression of REG Ⅲ and prognosis in head and neck cancer
Other Titles: 頭頸部癌におけるREG Ⅲ の発現と予後
Authors: Masui, Takashi
Ota, Ichiro
Itaya-Hironaka, Asako
Takeda, Maiko
Kasai, Takahiko
Yamauchi, Akiyo
Sakuramoto-Tsuchida, Sumiyo
Mikami, Shinji
Yane, Katsunari
Takasawa, Shin
Hosoi, Hiroshi
Keywords: REG Ⅲ
head and neck cancer
chemoradiosensitivity
Issue Date: Aug-2013
Publisher: National Hellenic Research Foundation / Spandidos
Citation: Oncology reports Vol.30 No.2 p.573-578
Abstract: Identification of a reliable biomarker for predicting prognosis in head and neck cancers is highly desirable and has long been sought. There have been several reports that members of the regenerating gene (REG) family are highly expressed in chronic inflammation and in tumors of the digestive organs. In addition, it has been described in several reports that REG expression is associated with the progression of digestive cancers. In the present study, we evaluated the effect of REG expression on the prognosis of hypopharyngeal cancer. We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method. According to these results, REG Ⅲ mRNA expression was significantly associated with prolonged survival. Therefore, we constructed hypopharyngeal cancer cell lines transfected with REG Ⅲ and assessed the cell proliferation and chemosensitivity and/or radiosensitivity in vitro. Cells transfected with REG Ⅲ exhibited significantly lower cell proliferation and higher chemosensitivity and/or radiosensitivity compared with the control cells. These data suggest that REG Ⅲ may be a reliable biomarker of prognosis in hypopharyngeal cancer. This is the first report concerning the association of REG Ⅲ expression and the prognosis of head and neck squamous cell carcinoma including hypopharyngeal cancer.
Description: 博士(医学)・甲第625号・平成27年3月16日
本文のリンク:http://dx.doi.org/10.3892/or.2013.2521
Copyright © Spandidos Publications 2014
URI: http://hdl.handle.net/10564/2937
ISSN: 1021335X
Academic Degrees and number: 24601A625
Degree-granting date: 2015-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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