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01221 博士論文(医学) >
2012年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/2789
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タイトル: | The dichotomy in the histogenesis of endometriosis-associated ovarian cancer: clear cell-type versus endometrioid-type adenocarcinoma. |
その他のタイトル: | 子宮内膜症と関連する卵巣癌 : 明細胞腺癌と類内膜腺癌の発癌機序における相違点 |
著者: | Kajihara, Hirotaka Yamada, Yoshihiko Shigetomi, Hiroshi![](/dspace/image/metalink/link_ja.gif) Higashiura, Yumi Kobayashi, Hiroshi![](/dspace/image/metalink/link_ja.gif) |
キーワード: | Endometriosis Ovarian cancer Endometrioid Clear cell Immunohistochemistry |
発行日: | 2012年6月 |
出版者: | Lippincott Williams & Wilkins / International Society of Gynecological Pathologists |
引用: | International journal of gynecological pathology Vol.31 No.4 p.304-312 |
抄録: | The histogenesis of endometriosis and endometriosis-associated ovarian cancer is one of the most mysterious aspects of pathology. To better understand the histogenesis of endometriosis and endometriosis-associated ovarian cancer, we analyzed the possibility of a link of endometrium, ovarian surface epithelium, and a cortical inclusion cyst to ovarian endometriosis and endometriosis-associated ovarian cancer by immunohistochemistry using the epithelial membrane antigen (an epithelial marker), calretinin (a mesothelial marker), and hepatocyte nuclear factor (HNF)-1β (a clear cell carcinoma-specific transcription factor). During ovarian surface epithelium invagination, cortical inclusion cyst epithelial cells may, in some cases, undergo mesothelial–epithelial transition and subsequently differentiate into endometriosis. This case of endometriosis that has undergone Müllerian metaplasia arises from the HNF-1β-negative cells. The remaining endometriosis may develop from the late secretory and menstrual endometria, with HNF-1β-positive staining, by retrograde menstruation. Endometrioid adenocarcinoma and clear cell carcinoma arise from the HNF-1β-negative and HNF-1β-positive epithelial cells of endometriosis, respectively. It has been proposed that clear cell and endometrioid-type adenocarcinomas arise from distinct types of endometriosis with different cells of origin. |
内容記述: | 博士(医学)・乙第1309号・平成25年3月15日 ©2012 International Society of Gynecological Pathologists |
URI: | http://hdl.handle.net/10564/2789 |
ISSN: | 02771691 |
DOI: | http://dx.doi.org/10.1097/PGP.0b013e318243a97b |
出現コレクション: | 2012年度
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