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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2789

Title: The dichotomy in the histogenesis of endometriosis-associated ovarian cancer: clear cell-type versus endometrioid-type adenocarcinoma.
Other Titles: 子宮内膜症と関連する卵巣癌 : 明細胞腺癌と類内膜腺癌の発癌機序における相違点
Authors: Kajihara, Hirotaka
Yamada, Yoshihiko
Shigetomi, Hiroshi
Higashiura, Yumi
Kobayashi, Hiroshi
Keywords: Endometriosis
Ovarian cancer
Endometrioid
Clear cell
Immunohistochemistry
Issue Date: Jun-2012
Publisher: Lippincott Williams & Wilkins / International Society of Gynecological Pathologists
Citation: International journal of gynecological pathology Vol.31 No.4 p.304-312
Abstract: The histogenesis of endometriosis and endometriosis-associated ovarian cancer is one of the most mysterious aspects of pathology. To better understand the histogenesis of endometriosis and endometriosis-associated ovarian cancer, we analyzed the possibility of a link of endometrium, ovarian surface epithelium, and a cortical inclusion cyst to ovarian endometriosis and endometriosis-associated ovarian cancer by immunohistochemistry using the epithelial membrane antigen (an epithelial marker), calretinin (a mesothelial marker), and hepatocyte nuclear factor (HNF)-1β (a clear cell carcinoma-specific transcription factor). During ovarian surface epithelium invagination, cortical inclusion cyst epithelial cells may, in some cases, undergo mesothelial–epithelial transition and subsequently differentiate into endometriosis. This case of endometriosis that has undergone Müllerian metaplasia arises from the HNF-1β-negative cells. The remaining endometriosis may develop from the late secretory and menstrual endometria, with HNF-1β-positive staining, by retrograde menstruation. Endometrioid adenocarcinoma and clear cell carcinoma arise from the HNF-1β-negative and HNF-1β-positive epithelial cells of endometriosis, respectively. It has been proposed that clear cell and endometrioid-type adenocarcinomas arise from distinct types of endometriosis with different cells of origin.
Description: 博士(医学)・乙第1309号・平成25年3月15日
©2012 International Society of Gynecological Pathologists
URI: http://hdl.handle.net/10564/2789
ISSN: 02771691
Appears in Collections:2012年度

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