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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2787

Title: Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet.
Other Titles: 終末糖化産物(AGE) は高リノール酸および高グルコース摂取下のアゾキシメタン投与F344 ラットの大腸粘膜においてAGE 受容体(RAGE) を発現誘導する
Authors: Shimomoto, Takasumi
Luo, Yi
Ohmori, Hitoshi
Chihara, Yoshitomo
Fujii, Kiyomu
Sasahira, Tomonori
Denda, Ayumi
Kuniyasu, Hiroki
Keywords: Colon carcinogenesis
Linoleic acid
Issue Date: Oct-2012
Publisher: Springer / Japanese Society of Gastroenterology
Citation: Journal of gastroenterology Vol.47 No.10 p.1073-1083
Abstract: BACKGROUND:Advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) are closely associated with colorectal cancer progression. The association between RAGE and AGE in colon carcinogenesis needs to be clarified.METHODS:Levels of RAGE and AGE were examined in azoxymethane (AOM)-injected Fischer 344 rats fed a control diet (Group C), a 15 % linoleic acid (LA) diet (Group L), a control diet with 10 % glucose drink (Group G), and a 15 % LA diet with 10 % glucose drink (Group L + G). Group L + G showed the most pronounced increase of body weight, blood sugar, and serum insulin.RESULTS:The rats in Group L + G showed the most pronounced multiplicity of aberrant crypt foci (ACF) and carcinomas with increased mucosal RAGE and AGE. IEC6 rat intestinal epithelial cells treated with AGE showed increased RAGE expression, which was inhibited by treatment with metformin or losartan. In the AOM-injected rat colon cancer model, the levels of RAGE and AGE, and the multiplicity of ACF and carcinomas, in Group L + G rats were suppressed by treatment with metformin or losartan.CONCLUSIONS:These results suggest that AGE-RAGE induced by high-LA and high-glucose diets substantially enhances colon cancer development; thus, suppression of AGE-RAGE could be a potential target for colon cancer chemoprevention.
Description: 博士(医学)・乙第1307号・平成25年3月15日
© Springer International Publishing AG,2012
© Japanese Society of Gastroenterology 2012
URI: http://hdl.handle.net/10564/2787
ISSN: 09441174
Appears in Collections:2012年度

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