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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2772

Title: Prognostic importance of tumour-infiltrating memory T cells in oesophageal squamous cell carcinoma.
Other Titles: 食道扁平上皮癌における腫瘍浸潤メモリーT細胞の予後因子としての重要性について
Authors: Enomoto, Koji
Sho, Masayuki
Wakatsuki, Kohei
Takayama, Tomoyoshi
Matsumoto, Sohei
Nakamura, Shinji
Akahori, Takahiro
Tanaka, Tetsuya
Migita, Kazuhiro
Ito, Masahiro
Nakajima, Yoshiyuki
Keywords: CD45RO
memory cells
oesophagus
prognosis
surgery
Issue Date: May-2012
Publisher: Blackwell Scientific Publications / British Society for Immunology
Citation: Clinical and experimental immunology Vol.168 No.2 p.186-191
Abstract: Memory T cells survive for many months and years and are critically important for host defence in humans. In tumour immunity, they have been also suggested to play a significant role in tumour progression and metastasis. However, the role of memory T cells in actual human cancer remains largely unknown. In this study, the clinical importance of tumour-infiltrating CD45RO(+) memory T cells was investigated in human oesophageal squamous cell carcinoma (OSCC). CD45RO(+) T cells were evaluated by immunohistochemistry in primary OSCC tumours from 105 patients. Patients were classified into two groups as CD45RO(+hi) or CD45RO(+lo) based on the number of cells stained positively for CD45RO. No significant difference was observed between CD45RO status and several clinicopathological prognostic factors. However, the postoperative overall and disease-free survival for CD45RO(+hi) patients was significantly better than for CD45RO(+lo) patients. Furthermore, there were significant correlations of CD45RO status in the primary tumour with postoperative lymph node and pulmonary recurrence, suggesting that memory T cells may control postoperative metastatic recurrence. Most importantly, CD45RO(+) memory T cell status has a significant prognostic value for OSCC independently of conventional tumour-node-metastasis (TNM) classification. Our study may provide a rationale for developing a novel immunotherapy in intentional induction of memory T cells for the treatment of oesophageal cancer.
Description: 博士(医学)・乙第1300号・平成24年7月26日
© 2012 The Authors;Clinical and Experimental Immunology
© 2012 British Society for Immunology
URI: http://hdl.handle.net/10564/2772
ISSN: 00099104
Appears in Collections:2012年度

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