GINMU >
01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2012年度 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/2771
|
Title: | A comparison of epidermal growth factor receptor expression in malignant peritoneal and pleural mesothelioma. |
Other Titles: | 腹膜および胸膜悪性中皮腫におけるEGFR発現の比較 |
Authors: | Enomoto, Yasunori Kasai, Takahiko Takeda, Maiko Takano, Masato Morita, Kouhei Kadota, Eiji Iizuka, Norishige Maruyama, Hiroshi Haratake, Joji Kojima, Yu Ikeda, Naoya Nonomura, Akitaka |
Keywords: | epidermal growth factor receptor FISH gene copy number gain immunohistochemistry malignant mesothelioma |
Issue Date: | Apr-2012 |
Publisher: | Blackwell Scientific Pub. for the Japanese Society of Pathology |
Citation: | Pathology international Vol.62 No.4 p.226-231 |
Abstract: | An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in malignant pleural and peritoneal mesothelioma was undertaken, using immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. Thirty-eight malignant mesothelioma (MM) specimens were subjected to IHC staining and FISH to evaluate the expression of EGFR protein and gene status. Overall positive IHC reaction was detected in 20/38 (53%) cases, in 11/22 (50%) pleural MM, and in 9/16 (56%) peritoneal MM. Our study confirmed that EGFR membranous expression is a common feature in MM, but not in benign mesothelial lesion. Thirty-seven cases did not show a gene copy number gain. Only one case showed a copy number gain. The protein overexpression of EGFR was not related to a gene copy number gain. |
Description: | 博士(医学)・乙第1299号・平成24年5月28日 © 2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd. |
URI: | http://hdl.handle.net/10564/2771 |
ISSN: | 13205463 |
DOI: | http://dx.doi.org/10.1111/j.1440-1827.2011.02778.x |
Appears in Collections: | 2012年度
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|