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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2771

Title: A comparison of epidermal growth factor receptor expression in malignant peritoneal and pleural mesothelioma.
Other Titles: 腹膜および胸膜悪性中皮腫におけるEGFR発現の比較
Authors: Enomoto, Yasunori
Kasai, Takahiko
Takeda, Maiko
Takano, Masato
Morita, Kouhei
Kadota, Eiji
Iizuka, Norishige
Maruyama, Hiroshi
Haratake, Joji
Kojima, Yu
Ikeda, Naoya
Nonomura, Akitaka
Keywords: epidermal growth factor receptor
gene copy number gain
malignant mesothelioma
Issue Date: Apr-2012
Publisher: Blackwell Scientific Pub. for the Japanese Society of Pathology
Citation: Pathology international Vol.62 No.4 p.226-231
Abstract: An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in malignant pleural and peritoneal mesothelioma was undertaken, using immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. Thirty-eight malignant mesothelioma (MM) specimens were subjected to IHC staining and FISH to evaluate the expression of EGFR protein and gene status. Overall positive IHC reaction was detected in 20/38 (53%) cases, in 11/22 (50%) pleural MM, and in 9/16 (56%) peritoneal MM. Our study confirmed that EGFR membranous expression is a common feature in MM, but not in benign mesothelial lesion. Thirty-seven cases did not show a gene copy number gain. Only one case showed a copy number gain. The protein overexpression of EGFR was not related to a gene copy number gain.
Description: 博士(医学)・乙第1299号・平成24年5月28日
© 2012 The Authors. Pathology International
© 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
URI: http://hdl.handle.net/10564/2771
ISSN: 13205463
Appears in Collections:2012年度

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