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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2723

Title: REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms.
Other Titles: 肺癌におけるREG Iα遺伝子の発現は、腺癌、肩平上皮癌で異なったメカニズムにより、予後不良を示唆する。
Authors: Kimura, Michitaka
Naito, Hiroshi
Tojo, Takashi
Itaya-Hironaka, Asako
Dohi, Yoshiko
Yoshimura, Mamiko
Nakagawara, Kan-Ichi
Takasawa, Shin
Taniguchi, Shigeki
Keywords: REG family genes
REG Iα gene
lung cancer
prognostic factor
gene expression
Issue Date: Dec-2013
Publisher: National Hellenic Research Foundation / Spandidos
Citation: Oncology reports Vol.30 No.6 p.2625-2631
Abstract: The aim of the present study was to evaluate the effects of the REG Iα and REG Iβ genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated. Lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) cell lines expressing REG Iα or REG Iβ (HLC-1 REG Iα/Iβ and EBC-1 REG Iα/Iβ) were established, and cell number, cell invasive activity, and anchorage-independent cell growth were compared with these variables in the control cells. The expression levels of REG family genes were evaluated by real-time RT-PCR in surgically resected lung cancers, and disease-specific survival (DSS) curves were generated. The HLC-1 REG Iα/Iβ cell line showed significant increases in cell number and anchorage-independent cell growth compared with the control cells. EBC-1 REG Iα/Iβ cells showed significant increases in cell invasive activity and anchorage-independent cell growth as compared with the control cells. Except for the REG Iβ gene, expression of other REG family genes was observed in the surgically resected samples; however, DSS was significantly worse only in stage I patients who were positive for REG Iα expression than in patients who were negative for REG Iα expression. The effects of REG Iα on AD and SCC cells were different in the in vitro study, and a correlation between REG Iα expression and patient prognosis was noted in the in vivo study. Therefore, overexpression of REG Iα is a risk factor for poor prognosis caused by discrete mechanisms in AD and SCC patients.
Description: 博士(医学)・乙第1339号・平成26年5月28日
Copyright © Spandidos Publications 2014
URI: http://hdl.handle.net/10564/2723
ISSN: 1021335X
Academic Degrees and number: 24601B1339
Degree-granting date: 2014-05-28
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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