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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2721

Title: Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma.
Other Titles: ヒト食道扁平上皮癌におけるherpesvirus entry mediator関与の重要性
Authors: Migita, Kazuhiro
Sho, Masayuki
Shimada, Keiji
Yasuda, Satoshi
Yamato, Ichiro
Takayama, Tomoyoshi
Matsumoto, Sohei
Wakatsuki, Kohei
Hotta, Kiyohiko
Tanaka, Tetsuya
Ito, Masahiro
Konishi, Noboru
Nakajima, Yoshiyuki
Keywords: esophageal squamous cell carcinoma
herpesvirus entry mediator (HVEM)
prognosis
immunotherapy
Issue Date: 15-Mar-2014
Publisher: American Cancer Society / Wiley
Citation: Cancer Vol.120 No.6 p.808-817
Abstract: BACKGROUND:Herpesvirus entry mediator (HVEM) is known to regulate immune response and to be expressed in several human malignancies. However, to the authors's knowledge, the precise role of HVEM in human cancer biology remains unknown. The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions.METHODS:HVEM expression was evaluated in 103 patients with esophageal squamous cell carcinoma to explore its clinical relevance and prognostic value. The functions of HVEM in tumors were analyzed in vitro and in vivo using the small interfering RNA (siRNA) silencing technique. RESULTS:HVEM expression was found to be significantly correlated with depth of tumor invasion and lymph node metastasis. Furthermore, it was found to be inversely correlated with tumor-infiltrating CD4(+) , CD8(+) , and CD45RO(+) lymphocytes. It is important to note that HVEM status was identified as an independent prognostic marker. HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo. This antitumor effect was associated with reduced cell proliferation activity. The effect was also correlated with the induction of CD8(+) cells and upregulation of local immune response.CONCLUSIONS:HVEM plays a critical role in both tumor progression and the evasion of host antitumor immune responses, possibly through direct and indirect mechanisms. Therefore, HVEM may be a promising therapeutic target for human esophageal cancer.
Description: 博士(医学)・乙第1337号・平成26年5月28日
Copyright © 1999-2015 John Wiley & Sons, Inc. All Rights Reserved.
© 2013 American Cancer Society
URI: http://hdl.handle.net/10564/2721
ISSN: 0008543X
Academic Degrees and number: 24601B1337
Degree-granting date: 2014-05-28
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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