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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2720

Title: Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma.
Other Titles: 食道扁平上皮癌におきてエンドセリンB受容体の高発現は腫瘍の血管新生と予後に関与する
Authors: Tanaka, Tetsuya
Sho, Masayuki
Takayama, Tomoyoshi
Wakatsuki, Kohei
Matsumoto, Sohei
Migita, Kazuhiro
Ito, Masahiro
Hamada, Kaoru
Nakajima, Yoshiyuki
Keywords: endothelin B receptor
oesophageal cancer
angiogenesis
Issue Date: Feb-2014
Publisher: Nature Publishing Group
Citation: British journal of cancer Vol.110 No.4 p.1027-1033
Abstract: BACKGROUND:The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC). METHODS:We evaluated ETBR expression in 107 patients with OSCC by immunohistochemistry. Microvessel density (MVD) and lymphatic vessel density were assessed by CD31 and D2-40 immunostaining, respectively. Furthermore, CD4, CD8, and CD45RO+ tumour-infiltrating lymphocytes (TILs) were immunohistochemically analysed.RESULTS:Sixty-one (57%) cases showed high expression of ETBR. Endothelin receptor type B expression was correlated with several clinicopathological factors including tumour differentiation, tumour depth, and lymph node metastasis. The overall and disease-specific survival rates were significantly lower in patients with high ETBR expression than patients with low expression. Furthermore, multivariate analysis revealed that ETBR status was an independent prognostic factor for patient survival. Mechanistic analysis indicated that MVD was significantly higher in tumour tissues with high ETBR expression compared with those with low expression, suggesting that angiogenesis may be a key mechanism in tumour progression and metastasis of OSCC mediated by ETBR expression. By contrast, there were no significant correlations between TILs and ETBR expression.CONCLUSION: Endothelin receptor type B has a pivotal role in oesophageal cancer and may be therapeutic target for this intractable malignancy.
Description: 博士(医学)・乙第1336号・平成26年5月28日
URI: http://hdl.handle.net/10564/2720
ISSN: 00070920
Academic Degrees and number: 24601B1336
Degree-granting date: 2014-05-28
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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